Calcified chondroid mesenchymal neoplasms with FN1-receptor tyrosine kinase gene fusions including FGFR2, FGFR1, MERTK, NTRK1, and TEK: a molecular and clinicopathologic analysis
Sign Up to like & getrecommendations! Published in 2021 at "Modern Pathology"
DOI: 10.1038/s41379-021-00786-x
Abstract: Translocations involving FN1 have been described in a variety of neoplasms that share the presence of a cartilage matrix and may also contain a variable extent of calcification. Fusions of FN1 to FGFR1 or FGFR2… read more here.
Keywords: gene fusions; soft tissue; gene; tyrosine kinase ... See more keywords
PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling
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DOI: 10.1080/13880209.2021.1944220
Abstract: Abstract Context The phosphorylation of signal transducer and activator of transcription protein 3 (STAT3) is up-regulated in glioblastoma (GBM) cells and is regulated by protein tyrosine phosphatase receptor type M (PTPRM). Fibronectin-1 (FN1) is also… read more here.
Keywords: methylation; stat3; ptprm methylation; phosphorylation ... See more keywords
High FN1 expression is associated with poor survival in esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000033388
Abstract: Esophageal cancer (EC) is a serious threat to human health. The expression of fibronectin 1 (FN1) in esophageal squamous cell carcinoma (ESCC) remains controversial. The purpose of this study was to elucidate the expression of… read more here.
Keywords: fn1 mrna; fn1; expression; fn1 protein ... See more keywords
Fn1 Regulates the Third Pharyngeal Pouch Patterning and Morphogenesis
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DOI: 10.1177/00220345221078775
Abstract: The parathyroid and thymus are derived from the common primordia, the third pharyngeal pouch. During their development, endodermal cells actively interact with surrounding mesenchymal cells, mainly derived from neural crest cells (NCCs). However, the mechanism… read more here.
Keywords: morphogenesis; pharyngeal pouch; fn1; thymus ... See more keywords
hsa_circ_0051428 Facilitates the Progression of Thyroid Cancer by Sponging miR-1248 to Up-Regulate FN1.
Sign Up to like & getrecommendations! Published in 2023 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2022044777
Abstract: Evidence displays that circular RNAs (circRNAs) are considerable mediators of numerous processes in cancer development. Given that many circRNAs are not functionally characterized, our aim was to explore the function and mechanisms of circ_0051428 in… read more here.
Keywords: mir 1248; fn1; cancer; circ 0051428 ... See more keywords
Circular RNA circCNOT6L regulates cell development through modulating miR-384/FN1 axis in esophageal squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202004_20830
Abstract: OBJECTIVE In recent years, circular RNAs (circRNAs) and microRNAs (miRNAs) have been shown to be related to the development of esophageal squamous cell carcinoma (ESCC). However, their functional mechanisms remain to be investigated. Herein, we… read more here.
Keywords: esophageal squamous; mir 384; escc; cell ... See more keywords
FN1 overexpression is correlated with unfavorable prognosis and immune infiltrates in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.913659
Abstract: Objective: To investigate the correlation of fibronectin 1 (FN1) expression with prognosis and tumor-infiltrating immune cells in breast cancer (BRCA). Methods: FN1 mRNA and protein expressions were analyzed through Tumor Immune Estimation Resource (TIMER), Gene… read more here.
Keywords: prognosis; fn1; expression; analysis ... See more keywords
Myo5b Transports Fibronectin-Containing Vesicles and Facilitates FN1 Secretion from Human Pleural Mesothelial Cells
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DOI: 10.3390/ijms23094823
Abstract: Pleural mesothelial cells (PMCs) play a central role in the progression of pleural fibrosis. As pleural injury progresses to fibrosis, PMCs transition to mesenchymal myofibroblast via mesothelial mesenchymal transition (MesoMT), and produce extracellular matrix (ECM)… read more here.
Keywords: pleural mesothelial; fn1; mesothelial cells; fn1 secretion ... See more keywords