Subchronic administration of creatine produces antidepressant-like effect by modulating hippocampal signaling pathway mediated by FNDC5/BDNF/Akt in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2018.07.001
Abstract: Creatine has been shown to play a significant role in the pathophysiology and treatment of major depressive disorder (MDD) in preclinical and clinical studies. However, the biological mechanisms underlying its antidepressant effect is still not… read more here.
Keywords: creatine; administration; fndc5 bdnf; effect ... See more keywords
Obesity caused by a high-fat diet regulates the Sirt1/PGC-1α/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older mice
Sign Up to like & getrecommendations! Published in 2019 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2019.1581460
Abstract: ABSTRACT Objectives: To investigate the effects of obesity caused by high-fat diet (HFD) on postoperative cognitive dysfunction (POCD) and expression of the Sirt1/PGC-1α/FNDC5/BDNF pathway in the hippocampus of older mice. Methods: Fifty-six 15-month-old male C57BL/6… read more here.
Keywords: bdnf pathway; fndc5 bdnf; sirt1 pgc; pgc fndc5 ... See more keywords