Sesamin Activates Skeletal Muscle FNDC5 Expression and Increases Irisin Secretion via the SIRT1 Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02794
Abstract: Sesamin, a major lignin mainly found in sesame (Sesamum indicum) oil and sesame seeds, has been demonstrated to possess lipoclasis-promoting, antiobesity, and antidiabetic effects. Irisin is a newly discovered myokine that has attracted great interest… read more here.
Keywords: irisin; sesamin; fndc5 expression; expression ... See more keywords
Interaction of CREB and PGC-1α Induces Fibronectin Type III Domain-Containing Protein 5 Expression in C2C12 Myotubes
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000494655
Abstract: Background/Aims: Fibronectin type III domain-containing protein 5 (FNDC5), also known as irisin, is a myokine secreted from muscle in response to exercise. However, the molecular mechanisms that regulate FNDC5 expression and the functional significance of… read more here.
Keywords: fndc5 expression; c2c12 myotubes; creb; expression ... See more keywords
Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression
Sign Up to like & getrecommendations! Published in 2023 at "eNeuro"
DOI: 10.1523/eneuro.0256-22.2023
Abstract: Abstract Major depressive disorder (MDD) is a major cause of disability in adults. MDD is both a comorbidity and a risk factor for Alzheimer’s disease (AD), and regular physical exercise has been associated with reduced… read more here.
Keywords: fndc5 expression; expression; cortex; mouse models ... See more keywords
Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice
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DOI: 10.3390/biom11020322
Abstract: Irisin is an exercise-induced myokine, suggested to exert beneficial effects on metabolism. However, the studies on the regulation of irisin secretion and the expression of its precursor FNDC5 have shown conflicting data. The discrepancies among… read more here.
Keywords: fndc5 expression; irisin; expression; mice ... See more keywords
The Role of Irisin/FNDC5 Expression and Its Serum Level in Breast Cancer
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DOI: 10.3390/ijms24108628
Abstract: Irisin (Ir) is an adipomyokine formed from fibronectin type III domain-containing protein 5 (FNDC5), which can be found in various cancer tissues. Additionally, FNDC5/Ir is suspected of inhibiting the epithelial-mesenchymal transition (EMT) process. This relationship… read more here.
Keywords: serum; breast; fndc5 expression; expression ... See more keywords