Lack of Adipocyte-Fndc5/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16602-z
Abstract: Irisin is a browning-stimulating molecule secreted from the fibronectin type III domain containing 5 precursor (FNDC5) by muscle tissue upon exercise stimulation. Despite its beneficial role, there is an unmet and clamorous need to discern… read more here.
Keywords: secretion; fndc5; irisin expression; fndc5 irisin ... See more keywords
FNDC5/Irisin polymorphisms are associated with osteopenia in postmenopausal Mayan-Mestizo women
Sign Up to like & getrecommendations! Published in 2022 at "Climacteric"
DOI: 10.1080/13697137.2022.2097866
Abstract: Abstract Objective This study aimed to analyze the association between rs3480 and rs16835198 of FNDC5/Irisin and their haplotypes with variations in bone mineral density (BMD) and osteopenia/osteoporosis in postmenopausal Mayan-Mestizo women. Methods We studied 547… read more here.
Keywords: femoral neck; mayan mestizo; total hip; mestizo women ... See more keywords
Exerkine fibronectin type-III domain-containing protein 5/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac431
Abstract: AIMS Exercise confers protection against cardiovascular ageing, but the mechanisms remain largely unknown. This study sought to investigate the role of fibronectin type-III domain-containing protein 5 (FNDC5)/irisin, an exercise-associated hormone, in vascular ageing. Moreover, the… read more here.
Keywords: irisin; fndc5; senescence; irisin enriched ... See more keywords
Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression
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DOI: 10.1523/eneuro.0256-22.2023
Abstract: Abstract Major depressive disorder (MDD) is a major cause of disability in adults. MDD is both a comorbidity and a risk factor for Alzheimer’s disease (AD), and regular physical exercise has been associated with reduced… read more here.
Keywords: fndc5 expression; expression; cortex; mouse models ... See more keywords
Effects of the FNDC5/Irisin on Elderly Dementia and Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.863901
Abstract: Population aging is an inevitable problem nowadays, and the elderly are going through a lot of geriatric symptoms, especially cognitive impairment. Irisin, an exercise-stimulating cleaved product from transmembrane fibronectin type III domain-containing protein 5 (FNDC5),… read more here.
Keywords: elderly dementia; cognitive impairment; irisin elderly; effects fndc5 ... See more keywords
Comparative Genomic Characterization of Buffalo Fibronectin Type III Domain Proteins: Exploring the Novel Role of FNDC5/Irisin as a Ligand of Gonadal Receptors
Sign Up to like & getrecommendations! Published in 2021 at "Biology"
DOI: 10.3390/biology10111207
Abstract: Simple Summary A total of 29 fibronectin type III domain (FN-III) protein genes from the buffalo genome were detected and characterized. The molecular and evolutionary analysis demonstrated the well-conserved nature of FN-III proteins with a… read more here.
Keywords: iii; buffalo; irisin ligand; fndc5 irisin ... See more keywords
FNDC5/Irisin: Physiology and Pathophysiology
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27031118
Abstract: A sedentary lifestyle or lack of physical activity increases the risk of different diseases, including obesity, diabetes, heart diseases, certain types of cancers, and some neurological diseases. Physical exercise helps improve quality of life and… read more here.
Keywords: physiology pathophysiology; irisin physiology; physiology; exercise ... See more keywords