Protein unfolding under isometric tension-what force can integrins generate, and can it unfold FNIII domains?
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DOI: 10.1016/j.sbi.2016.12.002
Abstract: Extracellular matrix fibrils of fibronectin (FN) are highly elastic, and are typically stretched three to four times their relaxed length. The mechanism of stretching has been controversial, in particular whether it involves tension-induced unfolding of… read more here.
Keywords: unfold fniii; fniii domains; protein unfolding; force ... See more keywords
NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor
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DOI: 10.1038/s41598-018-27089-7
Abstract: NCAM1 and NCAM2 have ectodomains consisting of 5 Ig domains followed by 2 membrane-proximal FnIII domains. In this study we investigate and compare the structures and functions of these FnIII domains. The NCAM1 and -2… read more here.
Keywords: fniii domains; domains form; neurite outgrowth; form rigid ... See more keywords