Long noncoding RNA THRIL promotes foam cell formation and inflammation in macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11934
Abstract: Tumor necrosis factor‐α (TNF‐α) and heterogenous nuclear ribonucleoprotein L (hnRNPL)‐related immunoregulatory lincRNA (THRIL) is a long noncoding RNA (lncRNA) involved in various inflammatory diseases. However, its role in atherosclerosis is not known. In this study,… read more here.
Keywords: inflammation; thril; foam cell; rna ... See more keywords
Mechanisms of foam cell formation in atherosclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1575-8
Abstract: Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is maintained by specialized cells, such as macrophages. Macrophages express a variety of scavenger receptors (SR) that interact with lipoproteins, including SR-A1, CD36, and lectin-like… read more here.
Keywords: foam cell; cell formation; formation atherosclerosis; cholesterol ... See more keywords
Clematichinenoside AR Alleviates Foam Cell Formation and the Inflammatory Response in Ox-LDL-Induced RAW264.7 Cells by Activating Autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01375-x
Abstract: Foam cell formation and inflammation in macrophages contribute to the development of atherosclerosis (AS). Clematichinenoside AR (AR) is a major active ingredient extracted from the traditional Chinese herb Clematis chinensis and has potent pharmacological effects… read more here.
Keywords: cell formation; foam cell; formation; induced raw264 ... See more keywords
Allergic asthma aggravated atherosclerosis increases cholesterol biosynthesis and foam cell formation in apolipoprotein E-deficient mice.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.09.085
Abstract: Several studies have demonstrated that allergic asthma can induce atherosclerosis formation in mice. Moreover, allergic asthma and atherosclerosis have been shown to be strongly associated with dyslipidemia. In this study, we investigated the underlying mechanism… read more here.
Keywords: foam cell; formation; cholesterol biosynthesis; mice ... See more keywords
Silencing LAIR‐1 in human THP‐1 macrophage increases foam cell formation by modulating PPAR&ggr; and M2 polarization
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.08.028
Abstract: Graphical abstract Figure. No caption available. HighlightsLAIR‐1 was down‐regulated in macrophage with the stimulation of ox‐LDL.Silencing expression of LAIR‐1 in human macrophages increased cholesterol uptake.LAIR‐1 activated phosphorylation of SHP‐1 and CREB to induce PPAR&ggr;, thus… read more here.
Keywords: cell formation; lair; foam cell; ppar ggr ... See more keywords
PPARα/γ signaling pathways are involved in Chlamydia pneumoniae-induced foam cell formation via upregulation of SR-A1 and ACAT1 and downregulation of ABCA1/G1.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2021.105284
Abstract: Chlamydia pneumoniae (Cpn) has been reported to be involved in the pathogenesis of early atherosclerosis by inducing macrophage-derived foam cell formation in the presence of low-density lipoprotein (LDL). However, the biochemical mechanisms underlying Cpn-induced foam… read more here.
Keywords: ppar; foam cell; cell formation;
Decidua basalis and acute atherosis: Expression of atherosclerotic foam cell associated proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Placenta"
DOI: 10.1016/j.placenta.2021.03.001
Abstract: INTRODUCTION Uteroplacental acute atherosis is frequently observed in preeclampsia, and shares features with early atherosclerotic lesions, including artery wall foam cells. The lipid-associated proteins FABP4 (fatty acid binding protein 4), perilipin-2, and LOX-1 (lectin-like oxidized… read more here.
Keywords: foam cell; acute atherosis; atherosis; decidua basalis ... See more keywords
Lipidomics Revealed the Suppression of 5-PAHSA from Human Milk on Macrophage Foam Cell Formation.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c06907
Abstract: Human milk contains bioactive lipids that provide long-term cardiovascular benefits, but the specific components and mechanisms remain unclear. This study aimed to identify lactation stage-specific lipid changes and assess the role of 5-palmitic acid ester… read more here.
Keywords: human milk; pahsa; foam cell; milk ... See more keywords
SARS-CoV-2 infection induces pro-fibrotic and pro-thrombotic foam cell formation
Sign Up to like & getrecommendations! Published in 2025 at "Nature Microbiology"
DOI: 10.1038/s41564-025-02090-9
Abstract: COVID-19 and long COVID are characterized by a dysregulated immune response. However, the role of macrophages during viral infection is poorly defined. Here we demonstrate that SARS-CoV-2 infection results in increased macrophage numbers and extensive… read more here.
Keywords: sars cov; cov infection; infection; formation ... See more keywords
Targeting fatty acid synthase reduces aortic atherosclerosis and inflammation
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-07656-1
Abstract: Fatty acid synthase (FAS) is predominantly expressed in the liver and adipose tissue. It plays vital roles in de novo synthesis of saturated fatty acids and regulates insulin sensitivity. We previously demonstrated that serum circulating… read more here.
Keywords: acid synthase; aortic atherosclerosis; foam cell; fatty acid ... See more keywords
Papain exerts an anti-atherosclerosis effect with suppressed MPA-mediated foam cell formation by regulating the MAPK and PI3K/Akt-NF-κB pathways
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2023.2194531
Abstract: ABSTRACT Background Papain possesses a potential anti-atherosclerosis (AS) effect. This study aimed to explore the inhibitory effects of papain on the monocyte-platelet aggregates (MPAs)-mediated production of foam cells in vitro and AS in vivo. Research… read more here.
Keywords: mapk pi3k; pi3k akt; foam cell; akt pathways ... See more keywords