Focal adhesion alterations in G0‐positive melanoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5510
Abstract: Melanoma is a highly heterogeneous malignant tumor that exhibits various forms of drug resistance. Recently, reversal transition of cancer cells to the G0 phase of the cell cycle under the influence of therapeutic drugs has… read more here.
Keywords: adhesion alterations; alterations positive; melanoma; positive melanoma ... See more keywords
IL‐6 increases podocyte motility via MLC‐mediated focal adhesion impairment and cytoskeleton disassembly
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26546
Abstract: The disturbance of podocyte motility is an essential pathogenic mechanisms of foot process effacement during proteinuric diseases, and myosin light chain (MLC) is a pivotal component in regulating the motility of podocytes. Inflammatory cytokine interleukin‐6… read more here.
Keywords: cytoskeleton; focal adhesion; motility; mlc ... See more keywords
GTPase Regulator Associated with Focal Adhesion Kinase 1 (GRAF1) Immunoglobulin‐Associated Ataxia and Neuropathy
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13036
Abstract: To date, 10 patients with GTPase Regulator Associated with Focal Adhesion Kinase 1/Rho GTPase Activating Protein 26‐Immunoglobulin (GRAF1/ARHGAP26‐IgG) associated neurological disorders have been described, most with ataxia. read more here.
Keywords: focal adhesion; adhesion kinase; gtpase regulator; associated focal ... See more keywords
Focal Adhesion Isolation Assay Using ECM-Coated Magnetic Beads.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0962-0_4
Abstract: Focal adhesions are force sensitive structures that dynamically alter their composition, protein-protein interactions, and signaling in response to external mechanical stimuli. These dynamic changes are critical for focal adhesion function and are required for cellular… read more here.
Keywords: protein; focal adhesion; adhesion isolation; adhesion ... See more keywords
Essential Role of Sptan1 in Cochlear Hair Cell Morphology and Function Via Focal Adhesion Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02551-2
Abstract: Hearing loss is the most common human sensory deficit. Hearing relies on stereocilia, inserted into the cuticular plate of hair cells (HCs), where they play an important role in the perception of sound and its… read more here.
Keywords: focal adhesion; hair cell; hair; function ... See more keywords
Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion.
Sign Up to like & getrecommendations! Published in 2020 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2020.05.003
Abstract: The paxillin family of proteins, including paxillin, Hic-5, and leupaxin, are focal adhesion adaptor/scaffolding proteins which localize to cell-matrix adhesions and are important in cell adhesion and migration of both normal and cancer cells. Historically,… read more here.
Keywords: focal adhesion; adhesion; paxillin family; cancer ... See more keywords
Focal adhesion displacement magnitude is a unifying feature of tensional homeostasis.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.06.043
Abstract: Tensional homeostasis is widely recognized to exist at the length scales of organs and tissues, but the cellular length scale mechanism for tension regulation is not known. In this study, we explored whether tensional homeostasis… read more here.
Keywords: tensional homeostasis; homeostasis; focal adhesion; feature ... See more keywords
A Mathematical Analysis of Focal Adhesion Lifetimes and Their Effect on Cell Motility.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.02.003
Abstract: By analyzing the distributions of focal adhesion (FA) lifetimes from different cell types, we found that a gamma distribution best matched the experimental distributions. In all but one case, it was a unimodal, non-symmetric gamma… read more here.
Keywords: adhesion lifetimes; focal adhesion; cell; mathematical analysis ... See more keywords
Loss of Linc01060 induces pancreatic cancer progression through vinculin-mediated focal adhesion turnover.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.015
Abstract: There is currently limited knowledge regarding the involvement of long non-coding RNAs (lncRNAs) in cancer development. We aimed to identify lncRNAs with important roles in pancreatic cancer progression. We screened for lncRNAs that were differentially… read more here.
Keywords: focal adhesion; linc01060; pancreatic cancer; cancer progression ... See more keywords
Focal adhesion kinase signaling regulates anti-inflammatory function of bone marrow mesenchymal stromal cells induced by biomechanical force.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.06.012
Abstract: Mesenchymal stromal cells (MSCs) have tremendous potential for use in regenerative medicine due to their multipotency and immune cell regulatory functions. Biomimetic physical forces have been shown to direct differentiation and maturation of MSCs in… read more here.
Keywords: focal adhesion; mesenchymal stromal; adhesion kinase; stromal cells ... See more keywords
Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53‐P21 axis, TGF‐beta signaling and focal adhesion that is TLR4 dependent
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.08.040
Abstract: ABSTRACT SsnB previously showed a promising role to lessen liver inflammation observed in a mouse model of NAFLD. Since NAFLD can progress to fibrosis, studies were designed to unravel its role in attenuating NAFLD associated… read more here.
Keywords: focal adhesion; fibrosis; ssnb; tlr4 ... See more keywords