Quantitative Correlation of Nanotopography with Cell Spreading via Focal Adhesions Using Adipose‐Derived Stem Cells
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Biosystems"
DOI: 10.1002/adbi.202000092
Abstract: Nanotopography mimicking extracellular environments reportedly impact cell morphological changes; however, elucidating this relationship has been challenging. To control cellular responses using nanostructures, in this study, the quantitative relationship between nanotopography and cell spreading mediated by… read more here.
Keywords: cell spreading; area; nanotopography cell; focal adhesions ... See more keywords
Phosphoinositide Conversion Inactivates R‐RAS and Drives Metastases in Breast Cancer
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DOI: 10.1002/advs.202103249
Abstract: Abstract Breast cancer is the most prevalent cancer and a major cause of death in women worldwide. Although early diagnosis and therapeutic intervention significantly improve patient survival rate, metastasis still accounts for most deaths. Here… read more here.
Keywords: inactivates ras; phosphoinositide conversion; breast cancer; conversion inactivates ... See more keywords
Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions
Sign Up to like & getrecommendations! Published in 2022 at "Small Methods"
DOI: 10.1002/smtd.202200152
Abstract: Hemidesmosomes (HDs) are multiprotein complexes that firmly anchor epidermal cells to the basement membrane of skin through the interconnection of the cytoplasmic intermediate filaments with extracellular laminin 332 (Ln332). Considerably less attention has been paid… read more here.
Keywords: adhesion; hds; via hemidesmosomes; size ... See more keywords
Micropattern-controlled chirality of focal adhesions regulates the cytoskeletal arrangement and gene transfection of mesenchymal stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120751
Abstract: Cell chirality has been demonstrated to be important for controlling cell functions. However, it is not clear how the chirality of the extracellular microenvironment regulates cell adhesion and cytoskeletal structures and therefore affects gene transfection.… read more here.
Keywords: chirality focal; gene; gene transfection; focal adhesions ... See more keywords
Deconstructing the role of myosin contractility in force fluctuations within focal adhesions.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.03.025
Abstract: Force fluctuations exhibited in focal adhesions (FAs) that connect a cell to its extracellular environment, point to the complex role of the underlying machinery that controls cell migration. To elucidate the explicit role of myosin… read more here.
Keywords: focal adhesions; role myosin; role; contractility ... See more keywords
Cancer Biology: APC Delivers Kiss of Death to Focal Adhesions
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.07.028
Abstract: New work shows that the actin-nucleating ability of the adenomatous polyposis coli protein is required for disassembly of focal adhesions. Loss of this function in Apc mutant cells reduces directed cell migration, potentially explaining the… read more here.
Keywords: biology apc; apc delivers; biology; cancer biology ... See more keywords
Src-mediated tyrosine phosphorylation of Protein Kinase D2 at focal adhesions regulates cell adhesion
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10210-7
Abstract: Dependent on their cellular localization, Protein Kinase D (PKD) enzymes regulate different processes including Golgi transport, cell signaling and response to oxidative stress. The localization of PKD within cells is mediated by interaction with different… read more here.
Keywords: phosphorylation; adhesion; focal adhesions; protein kinase ... See more keywords
The phospho–caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-05-0278
Abstract: The caveolin scaffolding domain mediates the promigratory activity of Src-phosphorylated (on Y14) caveolin-1 and, specifically, regulation of vinculin tension in focal adhesions. This suggests that pY14Cav1 enhances cancer cell migration by promoting engagement of focal… read more here.
Keywords: caveolin scaffolding; scaffolding domain; caveolin; focal adhesions ... See more keywords
α–Catenin-dependent vinculin recruitment to adherens junctions is antagonistic to focal adhesions
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-02-0071
Abstract: Vinculin is a protein found in both focal adhesions (FAs) and adherens junctions (AJs) which regulates actin connectivity to these structures. Many studies have demonstrated that mechanical perturbations of cells result in enhanced recruitment of… read more here.
Keywords: vinculin; recruitment; vinculin recruitment; focal adhesions ... See more keywords
Correlative light and electron microscopy reveals fork-shaped structures at actin entry sites of focal adhesions
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059417
Abstract: Focal adhesions (FAs) are the main cellular structures to link the intracellular cytoskeleton to the extracellular matrix. FAs mediate cell adhesion, are important for cell migration and are involved in many (patho)-physiological processes. Here we… read more here.
Keywords: electron microscopy; focal adhesions; entry; microscopy ... See more keywords
ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.198200
Abstract: ABSTRACT The Twist1 transcription factor promotes tumor invasion and metastasis by inducing epithelial–mesenchymal transition (EMT) and invadopodia-mediated extracellular matrix (ECM) degradation. The critical transcription targets of Twist1 for mediating these events remain to be uncovered.… read more here.
Keywords: invasion; twist1; metastasis; tumor invasion ... See more keywords