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   Articles with "focal adhesions" as a keyword



Quantitative Correlation of Nanotopography with Cell Spreading via Focal Adhesions Using Adipose‐Derived Stem Cells

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recommendations! Published in 2020 at "Advanced Biosystems"

DOI: 10.1002/adbi.202000092

Abstract: Nanotopography mimicking extracellular environments reportedly impact cell morphological changes; however, elucidating this relationship has been challenging. To control cellular responses using nanostructures, in this study, the quantitative relationship between nanotopography and cell spreading mediated by… read more here.

Keywords: cell spreading; area; nanotopography cell; focal adhesions ... See more keywords

Phosphoinositide Conversion Inactivates R‐RAS and Drives Metastases in Breast Cancer

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202103249

Abstract: Abstract Breast cancer is the most prevalent cancer and a major cause of death in women worldwide. Although early diagnosis and therapeutic intervention significantly improve patient survival rate, metastasis still accounts for most deaths. Here… read more here.

Keywords: inactivates ras; phosphoinositide conversion; breast cancer; conversion inactivates ... See more keywords

A comparative analysis of paxillin and Hic‐5 proximity interactomes

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recommendations! Published in 2024 at "Cytoskeleton"

DOI: 10.1002/cm.21878

Abstract: Focal adhesions serve as structural and signaling hubs, facilitating bidirectional communication at the cell–extracellular matrix interface. Paxillin and the related Hic‐5 (TGFβ1i1) are adaptor/scaffold proteins that recruit numerous structural and regulatory proteins to focal adhesions,… read more here.

Keywords: paxillin; focal adhesions; hic paxillin; paxillin hic ... See more keywords

Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions

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recommendations! Published in 2022 at "Small Methods"

DOI: 10.1002/smtd.202200152

Abstract: Hemidesmosomes (HDs) are multiprotein complexes that firmly anchor epidermal cells to the basement membrane of skin through the interconnection of the cytoplasmic intermediate filaments with extracellular laminin 332 (Ln332). Considerably less attention has been paid… read more here.

Keywords: adhesion; hds; via hemidesmosomes; size ... See more keywords

Micropattern-controlled chirality of focal adhesions regulates the cytoskeletal arrangement and gene transfection of mesenchymal stem cells.

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recommendations! Published in 2021 at "Biomaterials"

DOI: 10.1016/j.biomaterials.2021.120751

Abstract: Cell chirality has been demonstrated to be important for controlling cell functions. However, it is not clear how the chirality of the extracellular microenvironment regulates cell adhesion and cytoskeletal structures and therefore affects gene transfection.… read more here.

Keywords: chirality focal; gene; gene transfection; focal adhesions ... See more keywords

Deconstructing the role of myosin contractility in force fluctuations within focal adhesions.

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recommendations! Published in 2022 at "Biophysical journal"

DOI: 10.1016/j.bpj.2022.03.025

Abstract: Force fluctuations exhibited in focal adhesions (FAs) that connect a cell to its extracellular environment, point to the complex role of the underlying machinery that controls cell migration. To elucidate the explicit role of myosin… read more here.

Keywords: focal adhesions; role myosin; role; contractility ... See more keywords
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Cancer Biology: APC Delivers Kiss of Death to Focal Adhesions

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recommendations! Published in 2017 at "Current Biology"

DOI: 10.1016/j.cub.2017.07.028

Abstract: New work shows that the actin-nucleating ability of the adenomatous polyposis coli protein is required for disassembly of focal adhesions. Loss of this function in Apc mutant cells reduces directed cell migration, potentially explaining the… read more here.

Keywords: biology apc; apc delivers; biology; cancer biology ... See more keywords

Src-mediated tyrosine phosphorylation of Protein Kinase D2 at focal adhesions regulates cell adhesion

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-10210-7

Abstract: Dependent on their cellular localization, Protein Kinase D (PKD) enzymes regulate different processes including Golgi transport, cell signaling and response to oxidative stress. The localization of PKD within cells is mediated by interaction with different… read more here.

Keywords: phosphorylation; adhesion; focal adhesions; protein kinase ... See more keywords

The phospho–caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration

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recommendations! Published in 2017 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e17-05-0278

Abstract: The caveolin scaffolding domain mediates the promigratory activity of Src-phosphorylated (on Y14) caveolin-1 and, specifically, regulation of vinculin tension in focal adhesions. This suggests that pY14Cav1 enhances cancer cell migration by promoting engagement of focal… read more here.

Keywords: caveolin scaffolding; scaffolding domain; caveolin; focal adhesions ... See more keywords

α–Catenin-dependent vinculin recruitment to adherens junctions is antagonistic to focal adhesions

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recommendations! Published in 2022 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e22-02-0071

Abstract: Vinculin is a protein found in both focal adhesions (FAs) and adherens junctions (AJs) which regulates actin connectivity to these structures. Many studies have demonstrated that mechanical perturbations of cells result in enhanced recruitment of… read more here.

Keywords: vinculin; recruitment; vinculin recruitment; focal adhesions ... See more keywords

Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions

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recommendations! Published in 2024 at "Molecular Human Reproduction"

DOI: 10.1093/molehr/gaae018

Abstract: Abstract Paxillin is a ubiquitously expressed adaptor protein integral to focal adhesions, cell motility, and apoptosis. Paxillin has also recently been implicated as a mediator of nongenomic androgen receptor (AR) signaling in prostate cancer and… read more here.

Keywords: paxillin; paxillin knockout; focal adhesions; androgen receptor ... See more keywords