Eprosartan: A closer insight into its neuroprotective activity in rats with focal cerebral ischemia–reperfusion injury
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22796
Abstract: Eprosartan (EPRO), an angiotensin receptor type‐1 (AT‐1) blocker, exhibited neuroprotective activities in ischemic stroke resulting from focal cerebral ischemia in rats. The current study aimed to clarify the neuroprotective role of EPRO in middle carotid… read more here.
Keywords: cerebral ischemia; group; focal cerebral; ischemia ... See more keywords
β-Caryophyllene Pretreatment Alleviates Focal Cerebral Ischemia-Reperfusion Injury by Activating PI3K/Akt Signaling Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2202-3
Abstract: Abstractβ-Caryophyllene (BCP) has been reported to be protective against focal cerebral ischemia–reperfusion (I/R) injury by its anti-oxidative and anti-inflammatory features. Recent study demonstrates that the BCP exhibits potential neuroprotection against I/R injury induced apoptosis, however,… read more here.
Keywords: akt; cerebral ischemia; reperfusion; focal cerebral ... See more keywords
Neuroprotective Effects of Lycium barbarum Polysaccharide on Focal Cerebral Ischemic Injury in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2293-x
Abstract: Increasing evidence demonstrates inflammation contributes to neuronal death following cerebral ischemia. Lycium barbarum polysaccharide (LBP) has been reported to prevent scopolamine-induced cognitive and memory deficits. We recently indicated that LBP exerts neuroprotective effect against focal… read more here.
Keywords: cerebral ischemic; ischemic injury; focal cerebral; injury mice ... See more keywords
Attenuation of the Induction of TLRs 2 and 4 Mitigates Inflammation and Promotes Neurological Recovery After Focal Cerebral Ischemia
Sign Up to like & getrecommendations! Published in 2021 at "Translational Stroke Research"
DOI: 10.1007/s12975-020-00884-z
Abstract: The intense inflammatory response triggered in the brain after focal cerebral ischemia is detrimental. Recently, we showed that the suppression of toll-like receptors (TLRs) 2 and 4 attenuates infarct size and reduces the expression of… read more here.
Keywords: recovery; cerebral ischemia; reperfusion; tlrs ... See more keywords
Luteoloside attenuates neuroinflammation in focal cerebral ischemia in rats via regulation of the PPAR&ggr;/Nrf2/NF‐&kgr;B signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.11.044
Abstract: &NA; Luteoloside, a flavonoid compound, has been reported to have anti‐inflammatory, anti‐oxidative, antibacterial, antiviral, anticancer, and cardioprotective effects, among others, but its neuroprotective effects have rarely been studied. The purpose of this study was to… read more here.
Keywords: kgr signaling; cerebral ischemia; focal cerebral; ppar ggr ... See more keywords
Neuroprotective effects of genistein-3′-sodium sulfonate on focal cerebral ischemia in rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.02.046
Abstract: In order to improve the poor water solubility of genistein (4',5,7-trihydroxyisoflavone), which is extracted from food sources such as tofu, soybeans, and kudzu, we sulfonated genistein to synthesize a relatively more water-soluble compound, namely genistein-3'-sodium… read more here.
Keywords: genistein sodium; sodium sulfonate; cerebral ischemia; focal cerebral ... See more keywords
Neuroprotective effect of Naomaitong extract following focal cerebral ischemia induced by middle cerebral artery occlusion in rats.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Traditional Chinese Medicine"
DOI: 10.1016/s0254-6272(17)30069-9
Abstract: Abstract Objective To examine the neuroprotective effect of extract from Naomaitong following focal cerebral ischemia reperfusion induced by occlusion of middle cerebral artery (MCA), and to determine the biochemical alterations in urine using proton nuclear… read more here.
Keywords: cerebral ischemia; focal cerebral; spectroscopy; occlusion ... See more keywords
Identification of optimal reference genes for gene expression studies in a focal cerebral ischaemia model—Spatiotemporal effects
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17284
Abstract: A proper reference gene (RG) is required to reliably measure mRNA levels in biological samples via quantitative reverse transcription PCR (RT‐qPCR). Various experimental paradigms require specific and stable RGs. In studies using rodent models of… read more here.
Keywords: focal cerebral; reference; brain; expression ... See more keywords
Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/7189421
Abstract: Background Focal cerebral ischemia induces distinct neuroinflammatory processes. We recently reported the extracellular phosphor-glyco-protein osteopontin (OPN) to directly affect primary microglia in vitro, promoting survival while shifting their inflammatory profile towards a more neutral phenotype.… read more here.
Keywords: permanent focal; cerebral ischemia; focal cerebral; ischemia ... See more keywords
Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9749461
Abstract: Quercetin, a naturally occurring flavonoid, is mainly extracted from tea, onions, and apples. It has the underlying neuroprotective effect on experimental ischemic stroke. A systematic review and meta-analysis were used to assess quercetin's efficacy and… read more here.
Keywords: quercetin; cerebral ischemia; focal cerebral; systematic review ... See more keywords
Fingolimod Does Not Reduce Infarction After Focal Cerebral Ischemia in Mice During Active or Inactive Circadian Phases
Sign Up to like & getrecommendations! Published in 2022 at "Stroke"
DOI: 10.1161/strokeaha.122.039932
Abstract: Background: It has been reported that the S1P (sphingosine 1-phosphate) receptor modulator fingolimod reduces infarction in rodent models of stroke. Recent studies have suggested that circadian rhythms affect stroke and neuroprotection. Therefore, this study revisited… read more here.
Keywords: focal cerebral; inactive circadian; cerebral ischemia; active inactive ... See more keywords