Focal lesions following intracerebral gene therapy for mucopolysaccharidosis IIIA.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51772
Abstract: OBJECTIVE Mucopolysaccharidosis type IIIA (MPSIIIA) caused by recessive SGSH variants results in sulfamidase deficiency, leading to neurocognitive decline and death. No disease-modifying therapy is available. The AAVance gene therapy trial investigates AAVrh.10 overexpressing human sulfamidase… read more here.
Keywords: intracerebral gene; mucopolysaccharidosis; focal lesions; therapy ... See more keywords
Current status of percutaneous testicular biopsy for focal lesions
Sign Up to like & getrecommendations! Published in 2018 at "Abdominal Radiology"
DOI: 10.1007/s00261-018-1560-x
Abstract: ObjectiveThe purpose of this review is to evaluate the current role of percutaneous testicular biopsy in the diagnosis of focal testicular lesions.ConclusionPercutaneous testicular biopsy can be either fine needle aspiration biopsy or trucut core needle… read more here.
Keywords: testicular biopsy; focal lesions; biopsy; status percutaneous ... See more keywords
Virtual calcium-suppression in dual energy computed tomography predicts metabolic activity of focal MM lesions as determined by fluorodeoxyglucose positron-emission-tomography.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2020.109502
Abstract: PURPOSE Recent studies showed that dual energy CT (DECT) allows for detection of bone marrow infiltration in multiple myeloma (MM) by obtaining virtual non-calcium (VNCa) images. This feasibility study investigated, if VNCa imaging might discriminate… read more here.
Keywords: focal lesions; fdg pet; metabolic activity; calcium suppression ... See more keywords
The functional relevance of dorsal motor systems for processing tool nouns– evidence from patients with focal lesions
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychologia"
DOI: 10.1016/j.neuropsychologia.2020.107384
Abstract: This study asks whether lesions in different parts of the brain have different effects on the processing of words typically used to refer to objects with and without action affordances, for example tools and animal… read more here.
Keywords: focal lesions; functional relevance; patients focal; dorsal motor ... See more keywords
Investigating the network consequences of focal brain lesions through comparisons of real and simulated lesions
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81107-9
Abstract: Given the increased interest in the functional human connectome, a number of computer simulation studies have sought to develop a better quantitative understanding of the effects of focal lesions on the brain’s functional network organization.… read more here.
Keywords: focal lesions; term; network; term consequences ... See more keywords
Real life data of MRI-targeted biopsy – experience from a single nonacademic centre using cognitive fusion and 1.5 tesla scanning
Sign Up to like & getrecommendations! Published in 2020 at "Scandinavian Journal of Urology"
DOI: 10.1080/21681805.2020.1812713
Abstract: Abstract Objectives To date, it is unknown whether systematic biopsies can be safely omitted in patients with unsuspicious MRI findings or if systematic biopsies should be required when targeting focal lesions (PI-RADS 3–5). Methods A… read more here.
Keywords: focal lesions; series; cognitive fusion; real life ... See more keywords
Treatment to suppression of focal lesions on positron emission tomography-computed tomography is a therapeutic goal in newly diagnosed multiple myeloma
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2017.177139
Abstract: Fluorine-18 fluorodeoxyglucose positron emission tomography with computed tomography attenuation correction (PET-CT) in myeloma can detect and enumerate focal lesions by the quantitative characterization of metabolic activity. The aim of this study was to determine the… read more here.
Keywords: tomography; focal lesions; suppression; positron emission ... See more keywords
Integration of genomic analysis and transcript expression of ABCC8 and KCNJ11 in focal form of congenital hyperinsulinism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1015244
Abstract: Background The focal form of CHI is caused by an autosomal recessive pathogenic variant affecting the paternal homologue of genes ABCC8 or KCNJ11 and a second somatic event specifically occurring in the affected islet of… read more here.
Keywords: focal form; focal lesions; expression; analysis ... See more keywords