Efficacy and safety of perampanel monotherapy in patients with focal‐onset seizures with newly diagnosed epilepsy or recurrence of epilepsy after a period of remission: The open‐label Study 342 (FREEDOM Study)
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DOI: 10.1002/epi4.12398
Abstract: Our study assessed perampanel monotherapy in patients (aged ≥12 years) with focal‐onset seizures (FOS) with or without focal to bilateral tonic‐clonic seizures (FBTCS) in Japan and South Korea. read more here.
Keywords: epilepsy; monotherapy patients; perampanel monotherapy; study ... See more keywords
Real‐world use of adjunctive perampanel for focal‐onset seizures in Italy: A mirroring clinical practice study of perampanel in adults and adolescents (AMPA)
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DOI: 10.1002/epi4.70068
Abstract: The AMPA study (Study 501; NCT04257604) was a multicenter, prospective, 12‐month observational study in Italy that evaluated the effectiveness and safety of adjunctive perampanel in patients with focal‐onset seizures (FOS), with or without focal to… read more here.
Keywords: focal onset; perampanel; onset seizures; study ... See more keywords
Alice in wonderland syndrome in an elderly patient with focal onset epilepsy
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DOI: 10.1016/j.jocn.2020.04.010
Abstract: Alice in wonderland syndrome (AIWS) is a rare perceptual disorder characterized by subjective distortions of visual and somatosensory perception. Symptoms of AIWS are attributable to functional and structural changes of the visual and somatosensory perceptual… read more here.
Keywords: epilepsy; wonderland syndrome; onset epilepsy; alice wonderland ... See more keywords
Anti-seizure effects of WS-3, a TRPM8 agonist, on focal onset seizure mouse model via reduction of extracellular glutamate levels
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DOI: 10.1038/s41386-025-02143-x
Abstract: The development of novel anti-seizure drugs targeting novel mechanisms is crucial, especially for patients with intractable epilepsy. Previous studies using focal onset seizure rodent models have demonstrated that Icilin and WS-3, agonists of the transient… read more here.
Keywords: anti seizure; focal onset; seizure; onset seizure ... See more keywords
Quality of life study for caregivers of people with uncontrolled focal-onset seizures.
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DOI: 10.1080/13696998.2021.2018871
Abstract: AIM The aim of this study was to capture and measure the impact of caregiving for an adult with uncontrolled drug-resistant focal-onset seizures (FOS) on the caregivers' quality of life (QoL), and to quantify the… read more here.
Keywords: study; quality life; focal onset; onset seizures ... See more keywords
Hemispheric differences in the duration of focal onset seizures
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DOI: 10.1111/ane.13356
Abstract: To assess hemispheric differences in the duration of focal onset seizures and its association with clinical and demographic factors. read more here.
Keywords: differences duration; focal onset; hemispheric differences; onset seizures ... See more keywords
PAC-FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures.
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DOI: 10.1111/epi.18592
Abstract: Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.… read more here.
Keywords: predictive validity; models highest; validity; focal onset ... See more keywords
Brivaracetam: a novel antiepileptic drug for focal-onset seizures
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DOI: 10.1177/1756285617742081
Abstract: Brivaracetam (BRV), the n-propyl analogue of levetiracetam (LEV), is the latest antiepileptic drug (AED) to be licensed in Europe and the USA for the adjunctive treatment of focal-onset seizures with or without secondary generalization in… read more here.
Keywords: drug; focal onset; onset seizures; brv ... See more keywords
Primary Lateral Sclerosis Presenting With Focal Onset Spreading Through Contiguous Neuroanatomic Regions
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DOI: 10.1212/wnl.0000000000200011
Abstract: A 66-year-old woman complained of a 3-year history of left ankle focal spasticity. Brain MRI revealed subcortical white matter hyperintensity in the medial region of the right precentral gyrus. Subsequently, motor impairment spread proximally, to… read more here.
Keywords: focal onset; primary lateral; lateral sclerosis; sclerosis presenting ... See more keywords
Developing a Conceptual Disease Model of Patient Experiences and Identifying Patient-Reported Clinical Outcome Assessments for Use in Trials of Treatments for Focal Onset Seizures
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DOI: 10.2147/ndt.s354031
Abstract: Purpose To identify concepts important to understanding the experiences of adults with focal onset seizures (FOS) and evaluate clinical outcome assessments (COAs) for measuring these concepts in clinical trials of treatments for FOS. Methods A… read more here.
Keywords: focal onset; onset seizures; clinical trials; disease ... See more keywords
Non-Motor Manifestations in Idiopathic Dystonia with Focal Onset – A Pilot Study
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DOI: 10.25122/jml-2020-0094
Abstract: Recent studies emphasize an increased prevalence of non-motor symptoms in idiopathic dystonia with focal onset (IDFO), but their pathophysiological relationship is not clear. We aimed to identify the prevalence of depression and neurocognitive impairment in… read more here.
Keywords: dystonia focal; depression; non motor; study ... See more keywords