Hyperventilation‐induced focal seizures in adults: think autoimmune encephalitis
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DOI: 10.1002/acn3.51566
Abstract: Case reports have described rare patients with autoimmune encephalitis in whom focal seizures could be reliably provoked by hyperventilation. With the hypothesis that this phenomenon may have diagnostic significance, all cases of hyperventilation‐induced focal seizures… read more here.
Keywords: hyperventilation induced; hyperventilation; autoimmune encephalitis; induced focal ... See more keywords
The burden of epilepsy and unmet need in people with focal seizures
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DOI: 10.1002/brb3.2589
Abstract: Epilepsy is one of the most common neurological conditions worldwide. As a chronic condition, epilepsy imposes a significant burden on people with epilepsy and society. We aimed to assess the burden and unmet need of… read more here.
Keywords: need people; unmet need; focal seizures; epilepsy ... See more keywords
Modeling of Focal Seizures with Automatisms in Rats with Pendulum Movements
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DOI: 10.1007/s10517-019-04695-7
Abstract: Phenotypical study was carried out in rats with pendulum movements. The animals exhibited a high level of abortive seizures in response to audiogenic stimuli and longer postictal catalepsy in comparison with those in Wistar population.… read more here.
Keywords: modeling focal; rats pendulum; focal seizures; pendulum movements ... See more keywords
Pharmacokinetic evaluation of vigabatrin dose for the treatment of refractory focal seizures in children using adult and pediatric data
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2019.01.002
Abstract: Vigabatrin is indicated as adjunctive therapy for refractory focal seizures. For children, European recommendations indicate maintenance doses varying from 30 to 100 mg/kg/day for this indication. Since cumulated dose was associated with retinal toxicity, it is… read more here.
Keywords: adult; seizures children; focal seizures; refractory focal ... See more keywords
Effectiveness and tolerability of adjunctive brivaracetam in patients with focal seizures: Second interim analysis of 6-month data from a prospective observational study in Europe
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2020.106329
Abstract: Brivaracetam (BRV) is indicated for adjunctive treatment of focal (partial-onset) seizures with or without secondary generalisation in patients 4 years of age and older in the European Union (EU). An ongoing 12-month, prospective, non-interventional post-marketing… read more here.
Keywords: treatment; interim analysis; study; focal seizures ... See more keywords
Clinical and genetic characteristics of epilepsy of infancy with migrating focal seizures in Chinese children
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DOI: 10.1016/j.eplepsyres.2021.106669
Abstract: OBJECTIVE Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare and severe developmental epileptic encephalopathy. The aim of this study was to improve our understanding of EIMFS by using phenotype-genotype correlation. METHODS We… read more here.
Keywords: infancy migrating; focal seizures; migrating focal; clinical genetic ... See more keywords
High-frequency oscillations and focal seizures in epileptic rodents
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.12.016
Abstract: High-pass filtering (> 80 Hz) of EEG signals has enabled neuroscientists to analyze high-frequency oscillations (HFOs; i.e., ripples: 80-200 Hz and fast ripples: 250-500 Hz) in epileptic patients presenting with focal seizures and in animal models mimicking this… read more here.
Keywords: frequency oscillations; high frequency; focal seizures; seizures epileptic ... See more keywords
A de novo missense mutation in SLC12A5 found in a compound heterozygote patient with epilepsy of infancy with migrating focal seizures
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DOI: 10.1111/cge.13049
Abstract: Epilepsy of infancy with migrating focal seizures (EIMFS) is an infantile epileptic encephalopathy characterized by refractory seizures, severe psychomotor delay, and multiple moving epileptic discharges. The genetic etiology of EIMFS is relatively homogeneous with the… read more here.
Keywords: infancy migrating; focal seizures; migrating focal; epilepsy infancy ... See more keywords
Extrapolating evidence of antiepileptic drug efficacy in adults to children ≥2 years of age with focal seizures: The case for disease similarity
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DOI: 10.1111/epi.13859
Abstract: Expediting pediatric access to new antiseizure drugs is particularly compelling, because epileptic seizures are the most common serious neurological symptom in children. Analysis of antiepileptic drug (AED) efficacy outcomes of randomized controlled trials, conducted during… read more here.
Keywords: age; efficacy; drug; focal seizures ... See more keywords
G396(P) Clinical profile and underlying causes of focal epileptc seizures
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2017-313087.389
Abstract: Aims Focal seizures refer to the electrical and clinical manifestations of seizures that arise from one portion of the brain. The electroencephalogram (EEG) typically indicates a localised discharge over the area of onset. The aim… read more here.
Keywords: causes focal; focal seizures; underlying causes; partial seizures ... See more keywords
Decompression of a giant cranial pseudomeningocele causing haemiparesis and focal seizures
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DOI: 10.1136/bcr-2022-249345
Abstract: © BMJ Publishing Group Limited 2022. No commercial reuse. See rights and permissions. Published by BMJ. DESCRIPTION Postoperative pseudomeningoceles are characterised by extradural accumulation of cerebrospinal fluid (CSF) leaked from a surgical wound into the… read more here.
Keywords: haemiparesis; cranial pseudomeningocele; giant cranial; focal seizures ... See more keywords