Development of a Focused Library of Triazole‐Linked Privileged‐Structure‐Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections
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DOI: 10.1002/cmdc.201700786
Abstract: Protozoan infections caused by Plasmodium, Leishmania, and Trypanosoma spp. contribute significantly to the burden of infectious diseases worldwide, causing severe morbidity and mortality. The inadequacy of available treatments calls for cost‐ and time‐effective drug discovery… read more here.
Keywords: library triazole; triazole linked; focused library; phenotypic ... See more keywords
A Focused Library of NO‐Donor Compounds with Potent Antiproliferative Activity Based on Green Multicomponent Reactions
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DOI: 10.1002/cmdc.201900385
Abstract: Cancer is the second leading cause of death worldwide. Herein, a strategy to quickly and efficiently identify novel lead compounds to develop anticancer agents, using green multicomponent reactions followed by antiproliferative activity and structure–activity relationship… read more here.
Keywords: multicomponent reactions; green multicomponent; focused library; potent antiproliferative ... See more keywords