Decidual stromal cells support tolerance at the human foetal-maternal interface by inducing regulatory M2 macrophages and regulatory T-cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2021.103330
Abstract: During pregnancy, the semi-allogeneic nature of the foetus requires maternal immune adaption and acquisition of tolerance at the foetal-maternal interface. Macrophages with regulatory properties and regulatory T (Treg) cells are central in promoting foetal tolerance… read more here.
Keywords: tolerance; stromal cells; maternal interface; macrophages regulatory ... See more keywords
Pregnancy with successful foetal and maternal outcome in a melanoma patient treated with nivolumab in the first trimester: case report and review of the literature.
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DOI: 10.1097/cmr.0000000000000586
Abstract: Although T-cell checkpoint blockade has revolutionized melanoma therapy, metastatic melanoma in pregnancy remains a challenging area of unmet need. Treatment with anti-PD1 therapy decreases foetal-maternal tolerance and increases the risk of pregnancy loss in animal… read more here.
Keywords: foetal maternal; case; melanoma; pregnancy successful ... See more keywords
Uterine serpin (SERPINA 14) correlates negatively with cytokine production at the foetal–maternal interface but not in the corpus luteum in pregnant dairy heifers experimentally infected with Neospora caninum
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DOI: 10.1111/rda.12937
Abstract: This study examines gene expression patterns in dairy heifers experimentally infected with N. caninum during on Day 110 of pregnancy with live foetuses at euthanasia, 42 days later. The study population was constituted of four non-infected controls… read more here.
Keywords: maternal interface; gene expression; dairy heifers; expression ... See more keywords