Pathway analysis of genetic variants in folate‐mediated one‐carbon metabolism‐related genes and survival in a prospectively followed cohort of colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1407
Abstract: Folate‐mediated one‐carbon metabolism (FOCM) is a key pathway essential for nucleotide synthesis, DNA methylation, and repair. This pathway is a critical target for 5‐fluorouracil (5‐FU), which is predominantly used for colorectal cancer (CRC) treatment. A… read more here.
Keywords: folate mediated; mediated one; metabolism; related genes ... See more keywords
Doxorubicin-loaded folate-mediated pH-responsive micelle based on Bletilla striata polysaccharide: Release mechanism, cellular uptake mechanism, distribution, pharmacokinetics, and antitumor effects.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.123
Abstract: This study evaluated the potential of folate (FA)-mediated and stearic acid (SA) modified Bletilla striata polysaccharide (FA-BSP-SA) copolymer as the vehicle for targeted delivery of anticancer drugs to tumor tissues and enhanced antitumor efficacy. The… read more here.
Keywords: folate mediated; mechanism; dox bsp; bsp micelles ... See more keywords
Nitric oxide modulates folate-mediated one-carbon metabolism and mitochondrial energy levels of peaches during cold storage
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2023.1184736
Abstract: Folate-mediated one-carbon metabolism (FOCM) is closely associated with postharvest preservation. This study investigated the effects of exogenous nitric oxide (NO) on FOCM, storage quality, energy metabolism, and mitochondrial membrane integrity in cold-storage peach fruit. In… read more here.
Keywords: metabolism; energy; folate mediated; mediated one ... See more keywords
Vitamin C Activates the Folate-Mediated One-Carbon Cycle in C2C12 Myoblasts
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9030217
Abstract: Vitamin C (L-ascorbic acid, AA) is an essential cellular antioxidant and cofactor for several α-ketoglutarate-dependent dioxygenases. As an antioxidant, AA interacts with vitamin E to control oxidative stress. While several reports suggest an interaction of… read more here.
Keywords: folate mediated; mediated one; carbon cycle; c2c12 ... See more keywords