Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMN
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.04.048
Abstract: Background Exposure to anesthetics during early life may impair cognitive functions. However, the underlying mechanisms remain largely unknown. We set out to determine effects of sevoflurane anesthesia on folate metabolism and myelination in young non-human… read more here.
Keywords: ermn; disrupted folate; metabolism; anesthesia ... See more keywords
Simultaneous Detection of Three Genotypes of Gene Methylene Tetrahydrofolate Reductase and Methionine Synthase Reductase Based on Multiplex Asymmetric Real-Time PCR-HRM Biosensing.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02096
Abstract: Genotyping of folate metabolism genes is of great importance in disease diagnosis and prevention. However, most current detection methods used for folate metabolism gene genotyping are based on sequencing and chips, which suffer from a… read more here.
Keywords: folate metabolism; multiplex asymmetric; detection; reductase ... See more keywords
Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24036-5
Abstract: The mechanism behind transgenerational epigenetic inheritance is unclear, particularly through the maternal grandparental line. We previously showed that disruption of folate metabolism in mice by the Mtrr hypomorphic mutation results in transgenerational epigenetic inheritance of… read more here.
Keywords: biomarker; inheritance; folate metabolism; defective folate ... See more keywords
Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac020
Abstract: Abstract Folate metabolism plays an essential role in tumor development. Various cancers display therapeutic response to reagents targeting key enzymes of the folate cycle, but obtain chemoresistance later. Therefore, novel targets in folate metabolism are… read more here.
Keywords: metabolism; cell; growth; folate metabolism ... See more keywords
Folate metabolism genetic polymorphisms and meningioma and glioma susceptibility in adults
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18986
Abstract: Polymorphic variants of genes involved in folate metabolism are implicated in the susceptibility to meningioma and glioma, but the results from published articles are controversial and inconclusive. Therefore, we performed this meta-analysis including all studies… read more here.
Keywords: folate metabolism; meningioma; metabolism genetic; meningioma glioma ... See more keywords
Folate metabolism abnormalities in autism: potential biomarkers.
Sign Up to like & getrecommendations! Published in 2017 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2017-0109
Abstract: Autism spectrum disorder (ASD) has been linked to abnormalities in folate metabolism. Polymorphisms in folate genes may act in complex polygenic ways to increase the risk of developing ASD. Autoantibodies that block folate transport into… read more here.
Keywords: metabolism abnormalities; autism potential; metabolism; abnormalities autism ... See more keywords
Folate metabolism abnormalities in infertile patients with endometriosis.
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2021-0076
Abstract: Background: Homocysteine levels can be impacted by enzymes variations. Aim: To correlate MTHFR, MTR and MTRR variants with homocysteine levels in the blood and follicular fluid and assisted reproduction results. Material & methods: MTHFR (rs2274976,… read more here.
Keywords: abnormalities infertile; metabolism abnormalities; folate metabolism; homocysteine levels ... See more keywords
The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.01013
Abstract: Folate (vitamin B9) is a common name for a group of coenzymes that function as carriers of chemical moieties called one-carbon groups in numerous biochemical reactions. The combination of these folate-dependent reactions constitutes one-carbon metabolism,… read more here.
Keywords: folate; single nucleotide; folate metabolism; role ... See more keywords
Michael Adduct of Sulfonamide Chalcone Targets Folate Metabolism in Brugia Malayi Parasite
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11030723
Abstract: A series of Michael adducts of malononitrile and sulfonamide chalcones were synthesized, characterized, and evaluated for their antifilarial activity. Out of 14 compounds, N-(4-(4,4-dicyano-3-p-tolylbutanoyl)phenyl)benzenesulfonamide showed favorable drug-likeness properties with marked antifilarial effects at micro-molar dosages.… read more here.
Keywords: metabolism; folate metabolism; brugia malayi; chalcone ... See more keywords
Disruption of Cytosolic Folate Integrity Aggravates Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Modulates Metastatic Properties in Non-Small-Cell Lung Cancer Cells
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22168838
Abstract: Patients with advanced-stage non-small-cell lung cancer (NSCLC) are susceptible to malnutrition and develop folate deficiency (FD). We previously found that folate deprivation induces drug resistance in hepatocellular carcinoma; here, we assessed whether disrupted cytoplasmic folate… read more here.
Keywords: nsclc cells; folate metabolism; resistance; non small ... See more keywords