Folate receptor‐positive circulating tumor cells in the preoperative diagnosis of indeterminate pulmonary nodules
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24654
Abstract: The use of FR + CTC to distinguish lung cancer from benign lung disease has been well studied. However, the effective method to differentiate precursor glandular lesions from benign/malignant pulmonary diseases is rare. read more here.
Keywords: circulating tumor; cells preoperative; receptor positive; tumor cells ... See more keywords
Intraoperative Molecular Imaging Utilizing a Folate Receptor-Targeted Near-Infrared Probe Can Identify Macroscopic Gastric Adenocarcinomas
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-020-01549-x
Abstract: Purpose Current methods of assessing disease burden in gastric adenocarcinoma are imperfect. Improved visualization during surgery with intraoperative molecular imaging (IMI) could improve gastric adenocarcinoma staging and guide surgical decision-making. The goal of this study… read more here.
Keywords: intraoperative molecular; receptor targeted; folate receptor; molecular imaging ... See more keywords
The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-018-0589-2
Abstract: Macrophages play a key role in the pathophysiology of rheumatoid arthritis (RA). Notably, positive correlations have been reported between synovial macrophage infiltration and disease activity as well as therapy outcome in RA patients. Hence, macrophages… read more here.
Keywords: folate receptor; folate; rheumatoid arthritis; macrophage ... See more keywords
Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.03.031
Abstract: The delivery of small interfering RNA (siRNA) and its therapeutic usage as an anti-cancer agent requires a carrier system for selective internalization into the cytosol of tumor cells. We prepared folate-bearing formulations by first complexing… read more here.
Keywords: sirna lipopolyplexes; folate receptor; functionalization; sirna ... See more keywords
Correlation between the expression of folate receptor alpha (FRα) and clinicopathological features in patients with lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Lung cancer"
DOI: 10.1016/j.lungcan.2020.05.002
Abstract: OBJECTIVES Folate receptor alpha (FRα) is expressed on the cell surface, mediates its intracellular transport via receptor-mediated endocytosis, and is involved in cell division. Whether FRα could be a potential therapeutic target in FRα-expressing cancers… read more here.
Keywords: receptor alpha; expression; folate receptor; clinicopathological features ... See more keywords
Folate receptor‐beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2019.02.009
Abstract: Introduction Nonalcoholic steatohepatitis (NASH) afflicts 20–36% of individuals with nonalcoholic fatty liver disease (NAFLD). A lipotoxic hepatic environment, altered innate immune signaling and inflammation are defining features of progression to NASH. Activated resident liver macrophages… read more here.
Keywords: protein; bgr; nonalcoholic steatohepatitis; expression ... See more keywords
Characterization of folate receptor alpha (FRα) expression in archival tumor and biopsy samples in a phase I study of mirvetuximab soravtansine, a FRα-targeting antibody-drug conjugate (ADC), in relapsed epithelial ovarian cancer patients
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic Oncology"
DOI: 10.1016/j.ygyno.2017.03.089
Abstract: Characterization of folate receptor alpha (FRα) expression in archival tumor and biopsy samples in a Phase I study of mirvetuximab soravtansine, a FRα-targeting antibody drug conjugate (ADC), in relapsed epithelial ovarian cancer patients Lainie P.… read more here.
Keywords: expression archival; receptor alpha; characterization folate; alpha expression ... See more keywords
Reduced 18F-Folate Conjugates as a New Class of PET Tracers for Folate Receptor Imaging.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00775
Abstract: 5-Methyltetrahydrofolate (5-MTHF), a reduced folate form, is the biologically active folate involved in many different metabolic processes. To date, there are no studies available in the literature on 18F-labeled 6 S- and 6 R-5-MTHF radiotracers… read more here.
Keywords: 18f labeled; mthf; new class; folate conjugates ... See more keywords
Identification of a peptide for folate receptor alpha by phage display and its tumor targeting activity in ovary cancer xenograft
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-26683-z
Abstract: The expression level of folate receptor alpha (FRα) is located highly rate in ovarian cancer though it is remained absent in normal tissues. This highly tumor restricted expression profile makes FRα a promising target for… read more here.
Keywords: phage display; phage; receptor alpha; tumor targeting ... See more keywords
Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69682-9
Abstract: Folate receptor (FR)-targeted small molecule drug conjugates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizing agents, such as vintafolide and EC1456. In our effort to develop FR-targeted SMDCs with varying… read more here.
Keywords: crosslinking agent; dna crosslinking; dna; folate ... See more keywords
Hybrid polymeric nanoprobes for folate receptor-targeted photoacoustic imaging in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Materials Chemistry Frontiers"
DOI: 10.1039/c6qm00227g
Abstract: To construct biocompatible imaging nanoprobes and apply them to receptor-specific targeting of breast cancers is of great significance for precise diagnosis and personalized therapy serving nanomedicine. Herein, hybrid polymeric methylene blue-embedded nanoprobes (PBCA-MB@CS-FA) for folate… read more here.
Keywords: hybrid polymeric; photoacoustic imaging; receptor targeted; targeted photoacoustic ... See more keywords