Co-delivery of doxorubicin and SIS3 by folate-targeted polymeric micelles for overcoming tumor multidrug resistance.
Sign Up to like & getrecommendations! Published in 2021 at "Drug delivery and translational research"
DOI: 10.1007/s13346-020-00895-1
Abstract: Multidrug resistance (MDR) is considered as a critical limiting factor for the successful chemotherapy, which is mainly characterized by the overexpression of ATP-binding cassette (ABC) transporter ABCB1 or ABCG2. In this study, folate-targeted polymeric micellar… read more here.
Keywords: folate targeted; sis3; delivery; multidrug resistance ... See more keywords
Folate-targeted pH-sensitive bortezomib conjugates for cancer treatment.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc01344j
Abstract: In this study, a folate-targeted pH-sensitive bortezomib conjugate was developed for cancer-specific drug delivery and therapy. The conjugate showed improved cellular uptake, penetration, and anticancer activity compared to free bortezomib, a bortezomib-mannitol derivative, and a… read more here.
Keywords: folate targeted; bortezomib; cancer; sensitive bortezomib ... See more keywords
Folate-targeted polymeric nanoparticles for efficient dual (chemo-photothermal) therapy of oral squamous carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Polymeric Materials and Polymeric Biomaterials"
DOI: 10.1080/00914037.2020.1725756
Abstract: Abstract In this work, the phytochemical anticancer thymoquinone (TQ) and near-infrared plasmonic gold nanorods (AuNRs) were loaded in folate-targeted pegylated poly(d, l-lactide-co-glycolide) (PLGA-PEG-FA) nanocapsules. This polymeric regime exhibited in vitro sustained release kinetics of both… read more here.
Keywords: polymeric nanoparticles; folate targeted; targeted polymeric; chemo photothermal ... See more keywords
Folate-Targeted Redox-Responsive Polymersomes Loaded with Chemotherapeutic Drugs and Tariquidar to Overcome Drug Resistance.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2018.2623
Abstract: Tumor multidrug resistance (MDR) is a fatal obstacle to cancer chemotherapy. The combination of P-glycoprotein (P-gp) inhibitor and chemotherapeutic drugs is one of the effective strategies to reverse tumor MDR. Herein, a folate-decorated PCL-ss-PEG-ss-PCL based… read more here.
Keywords: redox responsive; folate targeted; drug; chemotherapeutic drugs ... See more keywords
Folate-Targeted PEGylated Magnetoliposomes for Hyperthermia-Mediated Controlled Release of Doxorubicin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.854430
Abstract: Doxorubicin (DOX) is a chemotherapeutic agent commonly used for the treatment of solid tumors. However, the cardiotoxicity associated with its prolonged use prevents further adherence and therapeutic efficacy. By encapsulating DOX within a PEGylated liposome,… read more here.
Keywords: folate targeted; targeted pegylated; dox; controlled release ... See more keywords
Folate-Targeted Liposomal Formulations Improve Effects of Methotrexate in Murine Collagen-Induced Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020229
Abstract: Methotrexate (MTX) is first-line therapy for the treatment of rheumatoid arthritis (RA), however, its use may be limited by side effects notably post-injection malaise. When patients are intolerant or become unresponsive, second-line or antibody therapy… read more here.
Keywords: folate targeted; induced arthritis; collagen induced; mtx ... See more keywords