A standardized fold change method for microarray differential expression analysis used to reveal genes involved in acute rejection in murine allograft models
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12343
Abstract: Murine transplantation models are used extensively to research immunological rejection and tolerance. Here we studied both murine heart and liver allograft models using microarray technology. We had difficulty in identifying genes related to acute rejections… read more here.
Keywords: microarray; allograft models; rejection; expression ... See more keywords
How consistent are we? Interlaboratory comparison study in fathead minnows using the model estrogen 17α-ethinylestradiol to develop recommendations for environmental transcriptomics.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.3799
Abstract: Fundamental questions remain about the application of omics in environmental risk assessments, such as the consistency of data across laboratories. The objective of the present study was to determine the congruence of transcript data across… read more here.
Keywords: consistent interlaboratory; estrogen; study; fathead minnows ... See more keywords
The effects of blanching on composition and modification of proteins in navy beans (Phaseolus vulgaris).
Sign Up to like & getrecommendations! Published in 2020 at "Food chemistry"
DOI: 10.1016/j.foodchem.2020.128950
Abstract: Blanching is an important process in the preparation of navy beans (Phaseolus vulgaris L.) for canning. We here explore the effect of blanching which can profoundly affect protein composition and introduce protein-primary-level modifications. Amino acid… read more here.
Keywords: protein; navy beans; beans phaseolus; phaseolus vulgaris ... See more keywords
Evidence of increased hypoxia signaling in fetal liver from maternal nutrient restriction in mice
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0447-z
Abstract: Background Intrauterine growth restriction (IUGR) is a pregnancy condition where fetal growth is reduced, and offspring from IUGR pregnancies are at increased risk for type II diabetes as adults. The liver is susceptible to fetal… read more here.
Keywords: increased hypoxia; maternal nutrient; change; nutrient restriction ... See more keywords
Machine learning compensates fold-change method and highlights oxidative phosphorylation in the brain transcriptome of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-93085-z
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder causing 70% of dementia cases. However, the mechanism of disease development is still elusive. Despite the availability of a wide range of biological data, a comprehensive understanding of… read more here.
Keywords: alzheimer disease; fold change; oxidative phosphorylation;
Input integration by the circadian clock exhibits nonadditivity and fold-change detection
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209933119
Abstract: Significance To optimize the cellular response, cells integrate information from diverse signals. The circadian clock is an internal mechanism that anticipates environmental daily changes, relying on various inputs to estimate the time of day. Yet,… read more here.
Keywords: circadian clock; fold change; clock; input integration ... See more keywords
15 Search for Non-Genomic Markers as Puberty Predictors inBos Indicus Cattle
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Animal Science"
DOI: 10.1093/jas/skad068.028
Abstract: Brahman cattle are used for crossbreeding due to their maternal ability, heat, and parasite tolerance. Brahman displays delayed attainment of puberty compared with taurine breeds. The objective was to identify molecular markers in the blood… read more here.
Keywords: genomic markers; search non; markers puberty; puberty ... See more keywords
PROTEOMIC PROFILE OF CYSTEINE OXIDATION IN VASCULAR SMOOTH MUSCLE CELLS IN HUMAN HYPERTENSION
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000837780.77360.72
Abstract: Objective: Phenotypic switching of vascular smooth muscle cells (VSMCs) is a fundamental process in vascular dysfunction and remodeling associated with hypertension. Mechanisms underlying this process involve reactive oxygen species (ROS) and redox-dependent signaling pathways. However,… read more here.
Keywords: hypertension; vascular smooth; fold change; human hypertension ... See more keywords
Fibroblast activation protein modulates left ventricular growth and matrix remodeling
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733029
Abstract: Background: Fibroblast Activation Protein (FAP) is abundantly expressed in cancer associated fibroblasts and contributes to activation of proteolytic cascades which alter extracellular matrix (ECM) remodeling. However, whether and to what degree FAP influences left ventricular… read more here.
Keywords: activation protein; fap; fibroblast activation; physiology ... See more keywords
A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-019-1906-3
Abstract: BackgroundQ fever fatigue syndrome (QFS) is a well-documented state of prolonged fatigue following around 20% of acute Q fever infections. It has been hypothesized that low grade inflammation plays a role in its aetiology. In… read more here.
Keywords: fatigue syndrome; fold change; log2 fold;
Transcriptional regulation in key metabolic pathways of Actinobacillus succinogenes in the presence of electricity.
Sign Up to like & getrecommendations! Published in 2023 at "Bioelectrochemistry"
DOI: 10.2139/ssrn.4197572
Abstract: The potential of renewable energy application via direct electrode interaction for the production of bio-based chemicals is a promising technology. The utilization of extracellular energy in pure culture fermentations aims in intracellular redox balance regulation… read more here.
Keywords: change; transcriptional regulation; fold change; regulation key ... See more keywords