One-Shot In Vitro Evolution Generated an Antibody Fragment for Testing Urinary Cotinine with More Than 40-Fold Enhanced Affinity.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.6b04332
Abstract: Immunoassays for cotinine, a major nicotine metabolite, in the urine are useful for monitoring the degree of tobacco smoke exposure. However, hybridoma-based anti-cotinine antibodies lack sufficient binding affinity to perform practically sensitive measurements, and thus… read more here.
Keywords: urinary cotinine; vitro evolution; one shot; cotinine ... See more keywords
1690-Fold enhanced electrochemiluminescence of gold nanoclusters via Zn2+ induced aggregation
Sign Up to like & getrecommendations! Published in 2025 at "Chemical Science"
DOI: 10.1039/d5sc06929g
Abstract: Herein, a zinc ion (Zn2+)-induced aggregation strategy is proposed for 1690-fold enhanced electrochemiluminescence (ECL) from d-penicillamine (DPA)-capped gold nanoclusters (AuNCs), and the aggregation-induced ECL (AIECL) is a multiplicative effect of two enhancing factors. One is… read more here.
Keywords: fold enhanced; induced aggregation; zn2 induced; aggregation ... See more keywords