Patterns of Antifungal Resistance in Adult Patients With Fungal Keratitis in South India: A Post Hoc Analysis of 3 Randomized Clinical Trials.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2021.5765
Abstract: Importance Antifungal resistance has been shown to impact treatment success, but research analyzing antifungal resistance is scarce. Objective To evaluate changes in antifungal resistance over time. Design, Setting, and Participants Ad hoc analysis of 3… read more here.
Keywords: hoc analysis; antifungal resistance; fold increase; resistance ... See more keywords
Nampt activator P7C3 ameliorates diabetes and improves skeletal muscle function modulating cell metabolism and lipid mediators.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12887
Abstract: BACKGROUND Nicotinamide phosphoribosyltransferase (Nampt), a key enzyme in NAD salvage pathway is decreased in metabolic diseases, and its precise role in skeletal muscle function is not known. We tested the hypothesis, Nampt activation by P7C3… read more here.
Keywords: fold increase; muscle; p7c3; p7c3 mice ... See more keywords
Exposure to neonicotinoids and serum testosterone in men, women, and children
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23503
Abstract: Neonicotinoids are the most used pesticides in the world and, despite being harmful to honeybees, they are considered safe for mammals. However, they have been associated with decreasing testosterone levels in several experimental animal models.… read more here.
Keywords: increase urinary; lower fold; serum testosterone; fold increase ... See more keywords
Nitrogen uptake pattern of herbaceous plants: coping strategies in altered neighbor species
Sign Up to like & getrecommendations! Published in 2017 at "Biology and Fertility of Soils"
DOI: 10.1007/s00374-017-1230-0
Abstract: The mechanisms for maintaining the species diversity of plant communities under conditions of resource limitation is an important subject in ecology. How interspecific relationships influence the pattern of nutrient absorption by coexisting species in N-limited… read more here.
Keywords: fold increase; nitrogen uptake; neighbor species; neighbor ... See more keywords
Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b04641
Abstract: Several studies suggest that an increase of glutathione (GSH) through activation of the transcriptional nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in the dopaminergic neurons may be a promising neuroprotective strategy in Parkinson's disease (PD). Among… read more here.
Keywords: neuroprotective effects; fold increase; comparison adaptive; parkinson disease ... See more keywords
Four-fold increase in solar forcing on snow in western U.S. burned forests since 1999
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09935-y
Abstract: Forest fires are increasing across the American West due to climate warming and fire suppression. Accelerated snow melt occurs in burned forests due to increased light transmission through the canopy and decreased snow albedo from… read more here.
Keywords: fold increase; burned forests; increase solar; four fold ... See more keywords
THU0050 CXCL13 IS A KEY DRIVER FOR MIGRATION AND DIFFERENTIATION OF REGULATORY B CELLS
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.3544
Abstract: Regulatory B cells in human still need to be characterized. Given the absence of a phenotypical definition of these cells, a functional definition based on their ability to secrete IL-10 is often used (corresponding to… read more here.
Keywords: migration; fold increase; ctl patients; b10 cells ... See more keywords
Ex Vivo Expansion with E478 Increases the Rate of CRISPR-Mediated Homology Directed Repair of the Beta-Globin Gene in Human Hematopoietic Stem Cells By >10-Fold and Improves In Vivo Engraftment By >120-Fold
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-131157
Abstract: Background . Site-specific gene correction of hematopoietic stem cells (HSCs) via homology directed repair (HDR) has the potential to precisely repair defective genes and provide life-long cures for a variety of blood-based diseases. It is… read more here.
Keywords: expansion; hdr; fold increase; e478 ... See more keywords
Transforming growth factor-β1 induces differentiation of rainbow trout (Oncorhynchus mykiss) cardiac fibroblasts into myofibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.189167
Abstract: ABSTRACT The collagen content of the rainbow trout heart increases in response to cold acclimation and decreases with acclimation to warm temperatures. This ability to remodel the myocardial extracellular matrix (ECM) makes these fish useful… read more here.
Keywords: fold increase; rainbow trout; cardiac fibroblasts; collagen ... See more keywords
Clinical Pharmacokinetics of Propranolol Hydrochloride: A Review.
Sign Up to like & getrecommendations! Published in 2020 at "Current drug metabolism"
DOI: 10.2174/1389200221666200414094644
Abstract: BACKGROUND Nobel laureate Sir James Black's molecule, propranolol, still has broad acceptance in cardiovascular diseases, infantile haemangiomas and anxiety. A comprehensive and systematic review of the literature for the summarization of pharmacokinetic parameters would be… read more here.
Keywords: clinical pharmacokinetics; hydrochloride review; fold increase; pharmacokinetics propranolol ... See more keywords
Intramammary infusion of lipopolysaccharide promotes inflammation and alters endometrial gene expression in lactating Holstein cows.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dairy science"
DOI: 10.3168/jds.2018-14393
Abstract: The objective of the current study was to evaluate the effects of 2 intramammary infusions of lipopolysaccharide (LPS) on inflammatory and reproductive parameters and endometrial gene expression of lactating Holstein cows. At 35 ± 7… read more here.
Keywords: fold increase; increase; gene expression; control lps ... See more keywords