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   Articles with "fold switching" as a keyword



Distinguishing features of fold‐switching proteins

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recommendations! Published in 2023 at "Protein Science"

DOI: 10.1002/pro.4596

Abstract: Though many folded proteins assume one stable structure that performs one function, a small‐but‐increasing number remodel their secondary and tertiary structures and change their functions in response to cellular stimuli. These fold‐switching proteins regulate biological… read more here.

Keywords: distinguishing features; fold switching; intrinsically disordered; fold switchers ... See more keywords

Mapping the energy landscape of a fold‐switching protein MAD2

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recommendations! Published in 2025 at "Protein Science"

DOI: 10.1002/pro.70329

Abstract: The mitotic arrest deficiency 2 (MAD2) exists in inactive and active forms under physiologic conditions. In its active conformation, MAD2 binds to the cell division cycle protein 20 (Cdc20) and prevents the separation of duplicated… read more here.

Keywords: protein; fold switching; energy landscape; mad2 ... See more keywords

In Silico Fold-Switching Protein Design Driven by Cα-Based Statistical Potential

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recommendations! Published in 2025 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.5c01435

Abstract: Structural plasticity of naturally occurring proteins allows them to change their shape in response to environmental factors such as pH, temperature, or binding partners. This ability to adopt different conformations is essential for many biological… read more here.

Keywords: sequence similarity; design; protein sequences; fold switching ... See more keywords

Morpheus: A fragment-based algorithm to predict fold-switching behaviour in proteins across proteomes.

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recommendations! Published in 2025 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btaf635

Abstract: Abstract Motivation Functionally important ‘fold-switching’ proteins, which do not obey the classical folding dogma, are now thought to be widespread. Algorithms that can accurately annotate fold-switching proteins from sequence information can help uncover the true… read more here.

Keywords: fragment based; switching behaviour; morpheus fragment; fold switching ... See more keywords