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   Articles with "foldamer" as a keyword



Helix Induction and Inversion of Polymeric Foldamer Regulated by the Single Enantiomers.

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recommendations! Published in 2022 at "Macromolecular rapid communications"

DOI: 10.1002/marc.202200238

Abstract: In general, a single enantiomer can induce a foldamer into a preferred-handed helix, while another condition is required for the helical inversion. In this work, it is found that the helix induction and subsequent inversion… read more here.

Keywords: helix induction; aza crown; inversion; single enantiomers ... See more keywords

Cell-Permeable Peptide Inhibitors of the p53-hDM2 Interaction via Foldamer Helix Mimicry and Bis-Thioether Stapling.

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recommendations! Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c01762

Abstract: Combining helical foldamers with α-peptides can produce α-helix mimetics with a reduced peptide character and enhanced resistance to proteolysis. Previously, we engineered a hybrid peptide-oligourea sequence replicating the N-terminal α-helical domain of p53 to achieve… read more here.

Keywords: permeable peptide; foldamer; helix; peptide ... See more keywords

Light-Mediated Interconversion between a Foldamer and a Self-Replicator

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recommendations! Published in 2024 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.4c09114

Abstract: Self-replicating molecules and well-defined folded macromolecules are of great significance in the emergence and evolution of life. How they may interconnect and affect each other remains largely elusive. Here, we demonstrate an abiotic system where… read more here.

Keywords: self replicating; foldamer; foldamer self; self replicator ... See more keywords
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Self-Assembled Protein-Aromatic Foldamer Complexes with 2:3 and 2:2:1 Stoichiometries.

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recommendations! Published in 2017 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.7b00184

Abstract: The promotion of protein dimerization using the aggregation properties of a protein ligand was explored and shown to produce complexes with unusual stoichiometries. Helical foldamer 2 was synthesized and bound to human carbonic anhydrase (HCA)… read more here.

Keywords: assembled protein; foldamer; aromatic foldamer; foldamer complexes ... See more keywords

Crystal structure of a protein-aromatic foldamer composite: macromolecular chiral resolution.

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recommendations! Published in 2019 at "Chemical communications"

DOI: 10.1039/c9cc05330a

Abstract: Co-crystallization of a 2 kDa tether-free sulfonated foldamer and the 13 kDa lysine-rich cytochrome c yielded a remarkable biohybrid assembly with chiral resolution of the foldamer helix handedness. In the crystal a ∼5 nm foldamer… read more here.

Keywords: crystal structure; foldamer; structure protein; chiral resolution ... See more keywords