DNA display of folded RNA libraries enabling RNA-SELEX without reverse transcription.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc09991b
Abstract: A method for the physical attachment of folded RNA libraries to their encoding DNA is presented as a way to circumvent the reverse transcription step during systematic evolution of RNA ligands by exponential enrichment (RNA-SELEX).… read more here.
Keywords: rna; folded rna; rna libraries; rna selex ... See more keywords
HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.69377
Abstract: Aberrant liquid-to-solid phase transitions of biomolecular condensates have been linked to various neurodegenerative diseases. However, the underlying molecular interactions that drive aging remain enigmatic. Here, we develop quantitative time-resolved crosslinking mass spectrometry to monitor protein… read more here.
Keywords: hspb8; phase transitions; folded rna; domain ... See more keywords