Co‐translational folding of α‐helical proteins: structural studies of intermediate‐length variants of the λ repressor
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12480
Abstract: Nascent polypeptide chains fold cotranslationally, but the atomic‐level details of this process remain unknown. Here, we report crystallographic, de novo modeling, and spectroscopic studies of intermediate‐length variants of the λ repressor N‐terminal domain. Although the… read more here.
Keywords: length; folding; variants repressor; intermediate length ... See more keywords
Effect of Protein Structure on Evolution of Cotranslational Folding.
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DOI: 10.1016/j.bpj.2020.06.037
Abstract: Cotranslational folding depends on the folding speed and stability of the nascent protein. It remains difficult, however, to predict which proteins cotranslationally fold. Here, we simulate evolution of model proteins to investigate how native structure… read more here.
Keywords: folding; contact; cotranslational folding; protein ... See more keywords
Cotranscriptional folding of RNA pseudoknots with different rates
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Physics Letters"
DOI: 10.1016/j.cplett.2021.138946
Abstract: Abstract We investigate and compare the refolding and cotranscriptional folding process of RNA pseudoknot including PK5 pseudoknot, human telomerase RNA (hTR) pseudoknot and its mutants by using helix-based transition rate model and master equation. It… read more here.
Keywords: folding; different rates; process; cotranscription ... See more keywords
Cotranslational Folding of a Pentarepeat β-Helix Protein.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.10.016
Abstract: It is becoming increasingly clear that many proteins start to fold cotranslationally before the entire polypeptide chain has been synthesized on the ribosome. One class of proteins that a priori would seem particularly prone to… read more here.
Keywords: pentarepeat; folding; cotranslational folding; helix protein ... See more keywords
Identifying Cross-individual Correspondences of 3-hinge Gyri
Sign Up to like & getrecommendations! Published in 2020 at "Medical image analysis"
DOI: 10.1016/j.media.2020.101700
Abstract: Human brain alignment based on imaging data has long been an intriguing research topic. One of the challenges is the huge inter-individual variabilities, which are pronounced not only in cortical folding patterns, but also in… read more here.
Keywords: folding; folding patterns; cross; structural functional ... See more keywords
Nanopore electric snapshots of an RNA tertiary folding pathway
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DOI: 10.1038/s41467-017-01588-z
Abstract: The chemical properties and biological mechanisms of RNAs are determined by their tertiary structures. Exploring the tertiary structure folding processes of RNA enables us to understand and control its biological functions. Here, we report a… read more here.
Keywords: folding; snapshots rna; nanopore electric; folding pathway ... See more keywords
Simple MD-based model for oxidative folding of peptides and proteins
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DOI: 10.1038/s41598-017-09229-7
Abstract: Significant strides have been recently made to fold peptides and small proteins in silico using MD simulations. However, facilities are currently lacking to include disulfide bonding in the MD models of protein folding. To address… read more here.
Keywords: simple based; folding; oxidative folding; model oxidative ... See more keywords
Cortex2vector: anatomical embedding of cortical folding patterns.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebral cortex"
DOI: 10.1093/cercor/bhac465
Abstract: Current brain mapping methods highly depend on the regularity, or commonality, of anatomical structure, by forcing the same atlas to be matched to different brains. As a result, individualized structural information can be overlooked. Recently,… read more here.
Keywords: cortical folding; different brains; folding; cortex2vector anatomical ... See more keywords
Vectorial folding of telomere overhang promotes higher accessibility
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac401
Abstract: Abstract Human telomere overhang composed of tandem repeats of TTAGGG folds into G-quadruplex (G4). Unlike in an experimental setting in the test tube in which the entire length is allowed to fold at once, inside… read more here.
Keywords: vectorial folding; folding; telomere overhang; higher accessibility ... See more keywords
Role of cotranslational folding for β-sheet-enriched proteins: A perspective from molecular dynamics simulations.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review. E"
DOI: 10.1103/physreve.105.024402
Abstract: The formations of correct three-dimensional structures of proteins are essential to their functions. Cotranslational folding is vital for proteins to form correct structures in vivo. Although some experiments have shown that cotranslational folding can improve… read more here.
Keywords: dynamics simulations; folding; cotranslational folding; sheet enriched ... See more keywords