Topological Polymorphism of Nucleosome Fibers and Folding of Chromatin.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.01.008
Abstract: We discuss recent observations of polymorphic chromatin packaging at the oligo-nucleosomal level and compare them with computer simulations. Our computations reveal two topologically different families of two-start 30-nm fiber conformations distinguished by the linker length,… read more here.
Keywords: nucleosome fibers; topological polymorphism; folding chromatin; polymorphism nucleosome ... See more keywords
A critical role for linker DNA in higher-order folding of chromatin fibers
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab058
Abstract: Abstract Nucleosome-nucleosome interactions drive the folding of nucleosomal arrays into dense chromatin fibers. A better physical account of the folding of chromatin fibers is necessary to understand the role of chromatin in regulating DNA transactions.… read more here.
Keywords: dna; chromatin; chromatin fibers; linker dna ... See more keywords