Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat
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DOI: 10.1002/pro.4396
Abstract: PDZ domains are the most diffused protein–protein interaction modules of the human proteome and are often present in tandem repeats. An example is PDZD2, a protein characterized by the presence of six PDZ domains that… read more here.
Keywords: folding intermediate; pdz; pdz domains; binding properties ... See more keywords
Identification and Characterization of an Inside-Out Folding Intermediate of T4 Phage Sliding Clamp.
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DOI: 10.1016/j.bpj.2017.08.043
Abstract: Protein folding process involves formation of transiently occurring intermediates that are difficult to isolate and characterize. It is both necessary and interesting to characterize the structural conformations adopted by these intermediates, also called molten globules… read more here.
Keywords: sliding clamp; phage; protein folding; gp45 ... See more keywords
Pharmacological inactivation of the prion protein by targeting a folding intermediate
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-020-01585-x
Abstract: Recent computational advancements in the simulation of biochemical processes allow investigating the mechanisms involved in protein regulation with realistic physics-based models, at an atomistic level of resolution. These techniques allowed us to design a drug… read more here.
Keywords: protein; targeting folding; inactivation; prion protein ... See more keywords