Landscape Zooming toward the Prediction of RNA Cotranscriptional Folding.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.1c01233
Abstract: RNA molecules fold as they are transcribed. Cotranscriptional folding of RNA plays a critical role in RNA functions in vivo. Present computational strategies focus on simulations where large structural changes may not be completely sampled.… read more here.
Keywords: folding landscape; rna folding; cotranscriptional folding; rna ... See more keywords
Comparing the folding landscapes of evolutionarily divergent procaspase-3
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DOI: 10.1101/2022.01.12.476064
Abstract: All caspases evolved from a common ancestor and subsequently developed into two general classes, inflammatory or apoptotic caspases. The caspase-hemoglobinase fold has been conserved throughout nearly one billion years of evolution and is utilized for… read more here.
Keywords: comparing folding; folding landscapes; landscapes evolutionarily; folding landscape ... See more keywords
Combining High-Pressure NMR and Geometrical Sampling to Obtain a Full Topological Description of Protein Folding Landscapes: Application to the Folding of Two MAX Effectors from Magnaporthe oryzae
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105461
Abstract: Despite advances in experimental and computational methods, the mechanisms by which an unstructured polypeptide chain regains its unique three-dimensional structure remains one of the main puzzling questions in biology. Single-molecule techniques, ultra-fast perturbation and detection… read more here.
Keywords: protein folding; max effectors; folding landscape; topological description ... See more keywords
Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants
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DOI: 10.7554/elife.61487
Abstract: Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer cases annually. Here we present a thermodynamic model that quantifies and links the major pathways by which mutations inactivate p53. We… read more here.
Keywords: shapes folding; cancer; zinc shapes; zinc ... See more keywords