Modulating SOD1 Folding Landscapes with Targeted Molecular Binders
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DOI: 10.1016/j.bpj.2016.11.928
Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by the deterioration of motor neurons that abates essential biological functions and exhibits survival times of 3 - 5 years after diagnosis. One driver of this… read more here.
Keywords: folding landscapes; landscapes targeted; targeted molecular; sod1 ... See more keywords
Comparing the folding landscapes of evolutionarily divergent procaspase-3
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1101/2022.01.12.476064
Abstract: All caspases evolved from a common ancestor and subsequently developed into two general classes, inflammatory or apoptotic caspases. The caspase-hemoglobinase fold has been conserved throughout nearly one billion years of evolution and is utilized for… read more here.
Keywords: comparing folding; folding landscapes; landscapes evolutionarily; folding landscape ... See more keywords