Folding the Mitochondrial UPR into the Integrated Stress Response.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2020.03.001
Abstract: Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to overcome environmental insults and respond to physiological cues. The mitochondrial unfolded protein response (UPRmt) is a mitochondrial-to-nuclear signaling pathway that maintains mitochondrial proteostasis,… read more here.
Keywords: response; mitochondrial upr; integrated stress; stress response ... See more keywords
Consequences of Folding the Mitochondrial Inner Membrane
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00536
Abstract: A fundamental first step in the evolution of eukaryotes was infolding of the chemiosmotic membrane of the endosymbiont. This allowed the proto-eukaryote to amplify ATP generation while constraining the volume dedicated to energy production. In… read more here.
Keywords: inner membrane; mitochondrial inner; consequences folding; topology ... See more keywords