Nanopore electric snapshots of an RNA tertiary folding pathway
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DOI: 10.1038/s41467-017-01588-z
Abstract: The chemical properties and biological mechanisms of RNAs are determined by their tertiary structures. Exploring the tertiary structure folding processes of RNA enables us to understand and control its biological functions. Here, we report a… read more here.
Keywords: folding; snapshots rna; nanopore electric; folding pathway ... See more keywords
Mapping the FF domain folding pathway via structures of transiently populated folding intermediates
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DOI: 10.1073/pnas.2416682121
Abstract: Significance Many protein molecules fold into well-defined functional structures. Although machine learning approaches enable accurate prediction of many of these structures, the mechanisms by which they fold remain elusive. Using solution NMR spectroscopy, we describe… read more here.
Keywords: pathway via; via structures; mapping domain; domain folding ... See more keywords
Relationship between Changes in the Protein Folding Pathway and the Process of Amyloid Formation: The Case of Bovine Carbonic Anhydrase II
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DOI: 10.3390/ijms232314645
Abstract: Many proteins form amyloid fibrils only under conditions when the probability of transition from a native (structured, densely packed) to an intermediate (labile, destabilized) state is increased. It implies the assumption that some structural intermediates… read more here.
Keywords: amyloid formation; protein folding; carbonic anhydrase; folding pathway ... See more keywords