Thermodynamic Linkage Analysis of pH-Induced Folding and Unfolding Transitions of I-Motifs
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DOI: 10.1016/j.bpj.2016.11.415
Abstract: We describe the pH-induced folding/unfolding transitions of i-motifs by a linkage thermodynamics-based formalism in terms of three pKa's of cytosines, namely, an apparent pKa in the unfolded conformation, pKau, and two apparent pKa's in the… read more here.
Keywords: transitions motifs; analysis; linkage; induced folding ... See more keywords
Naked-Eye Detection of Reversible Protein Folding and Unfolding in Aqueous Solution
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DOI: 10.1021/acs.jchemed.6b00507
Abstract: Students learning general chemistry and biochemistry often have difficulties understanding that proteins routinely exist in both folded and unfolded states, and that protein unfolding is not equivalent to irreversible denaturation or aggregation. To overcome the… read more here.
Keywords: protein; naked eye; detection reversible; solution ... See more keywords
Stimuli-Responsive Adaptive Nanotoxin to Directly Penetrate the Cellular Membrane by Molecular Folding and Unfolding.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c00084
Abstract: Biological nanomachines, including proteins and nucleic acids whose function is activated by conformational changes, are involved in every biological process, in which their dynamic and responsive behaviors are controlled by supramolecular recognition. The development of… read more here.
Keywords: folding unfolding; stimuli responsive; cellular membrane; responsive adaptive ... See more keywords
Chemomechanical-force-induced folding-unfolding directly controls distinct fluorescence dual-color switching.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc01643c
Abstract: Folding-unfolding imparts fluorescence dual color switching, thus a novel concept to switch fluorescence between two distinct colors while avoiding traditional bond rupturing and bond forming in photoswitching. Because folding and unfolding minimize the wear and… read more here.
Keywords: color switching; fluorescence; fluorescence dual; dual color ... See more keywords
Using anion recognition to control the folding and unfolding of a single chain phosphorescent polymer.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04895e
Abstract: We report here the use of anion recognition to control the folding and unfolding of a single polymeric chain consisting of a PMMA bearing pendant calix[4]pyrrole and Pt(ii) porphyrin subunits. read more here.
Keywords: recognition control; control folding; unfolding single; folding unfolding ... See more keywords
Non-Markovian modeling of protein folding
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2023856118
Abstract: Significance Protein-folding kinetics is often described as Markovian (i.e., memoryless) diffusion in a one-dimensional free energy landscape, governed by an instantaneous friction coefficient that is fitted to reproduce experimental or simulated folding times. For the… read more here.
Keywords: protein; non markovian; friction; protein folding ... See more keywords
Single-molecule mechanical folding and unfolding kinetics of armless mitochondrial tRNAArg from Romanomermis culicivorax
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DOI: 10.1088/1674-1056/ac1e1e
Abstract: The mechanical stability of tRNAs contributes to their biological activities. The mitochondrial tRNAArg from Romanomermis culicivorax is the shortest tRNA ever known. This tRNA lacks D- and T-arms, represents a stem–bulge–stem architecture but still folds… read more here.
Keywords: mechanical folding; trnaarg romanomermis; mitochondrial trnaarg; romanomermis culicivorax ... See more keywords
Folding–unfolding asymmetry and a RetroFold computational algorithm
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DOI: 10.1098/rsos.221594
Abstract: We treat protein folding as molecular self-assembly, while unfolding is viewed as disassembly. Fracture is typically a much faster process than self-assembly. Self-assembly is often an exponentially decaying process, since energy relaxes due to dissipation,… read more here.
Keywords: folding unfolding; protein folding; self assembly; algorithm ... See more keywords