Comparison of safety and efficacy of fluorouracil + oxaliplatin + irinotecan (FOLFOXIRI) and modified FOLFOXIRI with bevacizumab for metastatic colorectal cancer: data from clinical practice
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Colorectal Disease"
DOI: 10.1007/s00384-021-04064-9
Abstract: The efficacy of fluorouracil + oxaliplatin + irinotecan with bevacizumab (FOLFOXIRI + BV) has been verified for metastatic colorectal cancer (mCRC). In clinical practice, the original (O-FOLFOXIRI + BV) and modified dose settings (M-FOLFOXIRI + BV) are adopted for Asian patients. We aimed to compare… read more here.
Keywords: safety; group; efficacy; cancer ... See more keywords
FOLFOXIRI Regimen for Metastatic Colorectal Cancer: A Systematic Review and Meta‐Analysis
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DOI: 10.1016/j.clcc.2017.03.012
Abstract: Micro‐Abstract FOLFOXIRI regimen can improve outcomes for patients with mCRC. We performed a systematic review with meta‐analysis comparing FOLFOXIRI to less aggressive regimens. Four studies were included in the final analysis. The pooled data showed… read more here.
Keywords: folfoxiri regimen; analysis; colorectal cancer; folfoxiri ... See more keywords
Pathological response and safety of FOLFOXIRI for neoadjuvant treatment of high-risk relapsed locally advanced colon cancer: study protocol for a single-arm, open-label phase II trial
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DOI: 10.1136/bmjopen-2022-062659
Abstract: Introduction Neoadjuvant chemotherapy (NAC) has been demonstrated effective in several tumours, but its benefit has not yet been elucidated in colorectal cancer, especially locally advanced colorectal cancer (LACRC). Methods and analysis This is a single-arm,… read more here.
Keywords: study; trial; folfoxiri; treatment ... See more keywords
Impact of FOLFOXIRI and bevacizumab (bev) compared to FOLFOX and bev on health related quality of life (HRQOL) in patients with metastatic colorectal cancer (MCRC): Analysis of the CHARTA-AIO 0209 trial.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.3544
Abstract: 3544Background: FOLFOXIRI/bev is a highly efficacious first line regimen in MCRC. Despite higher rates of neutropenia, diarrhea and stomatitis, FOLFOXIRI/bev is tolerable and feasible in MCRC patients. To date nothing is known about the impact… read more here.
Keywords: folfox bev; mcrc; analysis; bev ... See more keywords
NIVACOR: Phase II study of nivolumab in combination with FOLFOXIRI/bevacizumab in first-line chemotherapy for advanced colorectal cancer RASm/BRAFm patients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.tps4118
Abstract: TPS4118Background: FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) plus bevacizumab has been shown to be one of the therapeutic regimens in first line with the highest activity pr... read more here.
Keywords: first line; nivacor phase; phase study; folfoxiri ... See more keywords
Single Nucleotide Polymorphisms in MiRNA Binding Sites of Nucleotide Excision Repair-Related Genes Predict Clinical Benefit of Oxaliplatin in FOLFOXIRI Plus Bevacizumab: Analysis of the TRIBE Trial
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12071742
Abstract: Background: The nucleotide excision repair (NER) pathway participates in platinum-induced DNA damage repair. Single nucleotide polymorphisms (SNPs) in miRNA-binding sites in the NER genes RPA2 and GTF2H1 are associated with the risk of colorectal cancer… read more here.
Keywords: nucleotide excision; analysis; excision repair; folfoxiri ... See more keywords