Follicle loss and PTEN/PI3K/mTOR signaling pathway activated in LepR-mutated mice
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DOI: 10.1080/09513590.2018.1490714
Abstract: Abstract Female mice (Y123F) with substitution mutations introduced through homologous gene targeting, replacing the three tyrosine residues of LepR, Tyr985, Tyr1077, and Tyr1138 with phenylalanine, could induce infertility. This study aimed to describe the reproductive… read more here.
Keywords: signaling pathway; mtor; mice; follicle loss ... See more keywords