Identification of Human Blood and Tissue T Follicular Regulatory (Tfr) Cells by Flow Cytometry.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1736-6_4
Abstract: T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells are crucially involved in the regulation of germinal center reactions. Thus, as key players, the assessment of these cell subsets is necessary for a… read more here.
Keywords: regulatory tfr; follicular regulatory; tfr cells; flow cytometry ... See more keywords
The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.07.004
Abstract: Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE… read more here.
Keywords: tfr cells; tfh; follicular regulatory; ratio ... See more keywords
T follicular helper cells and T follicular regulatory cells in rheumatic diseases
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-019-0254-2
Abstract: As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in diagnosis for decades. However, the immunological mechanism underlying their generation has only become clear following the identification of T follicular helper (TFH) cells… read more here.
Keywords: tfr cells; rheumatic diseases; follicular regulatory; tfh cells ... See more keywords
Association of follicular helper T and follicular regulatory T cells with severity and hyperglycemia in hospitalized COVID-19 patients
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2047506
Abstract: ABSTRACT We aimed to determine the levels of follicular helper T (Tfh) and follicular regulatory T (Tfr) cells in COVID-19 patients and determine whether their levels correlated with disease severity and presence of hyperglycemia. This… read more here.
Keywords: follicular helper; covid patients; tfr cells; tfh ... See more keywords
ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.1101/2021.09.14.460384
Abstract: ICOS signaling promotes T follicular regulatory cell differentiation during germinal center reaction safeguarding against autoantibody production. ICOS is a T-cell costimulatory receptor critical for Tfh cell generation and function. However, the role of ICOS in… read more here.
Keywords: cell; icos costimulation; follicular regulatory; differentiation ... See more keywords
ICOS+ follicular regulatory T cells are implicated in the pathogenesis of ulcerative colitis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13568
Abstract: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with a rising incidence worldwide. The precise aetiology is unclear, but aberrant regulatory T cell (Treg) responses have been documented in active UC patients. Follicular regulatory… read more here.
Keywords: icos; tfr cells; anti cd3; follicular regulatory ... See more keywords
THU0231 IL-2 DRIVES THE CONVERSION OF T FOLLICULAR HELPER TO T FOLLICULAR REGULATORY CELLS THROUGH EPIGENETIC MODIFICATION IN SYSTEMIC LUPUS ERYTHEMATOSUS
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.651
Abstract: Background: Systemic lupus erythematosus (SLE) is a complex polygenic autoimmune disease characterized by immune-system aberrations. Among several types of immune cells, T follicular helper (Tfh) cells promote autoantibody production, whereas T follicular regulatory (Tfr) cells… read more here.
Keywords: tfh; follicular regulatory; tfr cells; follicular helper ... See more keywords
The role of follicular regulatory T cells/follicular helper T cells in primary immune thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2023 at "Acta haematologica"
DOI: 10.1159/000529963
Abstract: Introduction Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia. Herein, we sought to identify potential immune-related therapeutic targets in ITP. Methods The differentially expressed genes (DEGs) between ITP patients and controls in GSE43177… read more here.
Keywords: itp patients; follicular helper; immune thrombocytopenia; follicular regulatory ... See more keywords
Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes.
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DOI: 10.2337/db21-0091
Abstract: In the attempt to understand the origin of autoantibody (AAb) production in patients with and at-risk for T1D, multiple studies have analyzed and reported alterations in follicular helper T cells (Tfh) in presymptomatic AAb-positive subjects… read more here.
Keywords: tfr cells; follicular regulatory; regulatory cells; pancreatic lymph ... See more keywords
Control of Germinal Center Responses by T-Follicular Regulatory Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01910
Abstract: Regulatory T-cells (Treg cells), expressing the transcription factor Foxp3, have an essential role in the control of immune homeostasis. In order to control diverse types of immune responses Treg cells must themselves show functional heterogeneity… read more here.
Keywords: treg cells; cells control; follicular regulatory; regulatory cells ... See more keywords
Control of the Germinal Center by Follicular Regulatory T Cells During Infection
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DOI: 10.3389/fimmu.2018.02704
Abstract: Follicular regulatory T cells (Tfr) are a unique subset of CD4 T cells that control and impact adaptive immune responses in the lymphoid follicles and germinal centers (GC). Since their relatively recent discovery, several studies… read more here.
Keywords: germinal center; center follicular; follicular regulatory; infection ... See more keywords