Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3.
Sign Up to like & getrecommendations! Published in 2022 at "PLoS biology"
DOI: 10.1371/journal.pbio.3001594
Abstract: Mechanistic target of rapamycin complex I (mTORC1) is central to cellular metabolic regulation. mTORC1 phosphorylates a myriad of substrates, but how different substrate specificity is conferred on mTORC1 by different conditions remains poorly defined. Here,… read more here.
Keywords: folliculin; tfe3; mtorc1; recruit tfe3 ... See more keywords
Folliculin Controls the Intracellular Survival and Trans-Epithelial Passage of Neisseria gonorrhoeae
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.00422
Abstract: Neisseria gonorrhoeae, a Gram-negative obligate human pathogenic bacterium, infects human epithelial cells and causes sexually transmitted diseases. Emerging multi-antibiotic resistant gonococci and increasing numbers of infections complicate the treatment of infected patients. Here, we used… read more here.
Keywords: intracellular survival; infection; neisseria gonorrhoeae; cell ... See more keywords