Partial and full deletion of nicotinic acetylcholine receptor α4 and β2 subunits reduces sensitivity to acute nicotine administration and development of tolerance following chronic nicotine administration
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000575
Abstract: Supplemental Digital Content is available in the text. The diversity of nicotinic cholinergic receptor (nAChR) subunits underlies the complex responses to nicotine. Mice differing in the expression of α4 and β2 subunits, which are most… read more here.
Keywords: administration; following chronic; tolerance; nicotine administration ... See more keywords
RAGE availability lessens the degree of dysfunctional mitochondrial bioenergetics following chronic secondhand smoke exposure
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DOI: 10.1152/physiol.2023.38.s1.5733415
Abstract: The receptor for advanced glycation end products (RAGE) is an immunoglobulin-type receptor abundantly expressed by lung parenchyma that coordinates inflammatory responses. We have previously described roles for RAGE following exposure to tobacco smoke (both primary… read more here.
Keywords: following chronic; mitochondrial bioenergetics; secondhand smoke; rage ... See more keywords
Altered Accumbal Dopamine Terminal Dynamics Following Chronic Heroin Self-Administration
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DOI: 10.3390/ijms23158106
Abstract: Administration of heroin results in the engagement of multiple brain regions and the rewarding and addictive effects are mediated, at least partially, through activation of the mesolimbic dopamine system. However, less is known about dopamine… read more here.
Keywords: following chronic; self administration; administration; heroin ... See more keywords
Morphine Accumulates in the Retina Following Chronic Systemic Administration
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DOI: 10.3390/ph15050527
Abstract: Opioid transport into the central nervous system is crucial for the analgesic efficacy of opioid drugs. Thus, the pharmacokinetics of opioid analgesics such as morphine have been extensively studied in systemic circulation and the brain.… read more here.
Keywords: following chronic; retina following; morphine accumulates; accumulates retina ... See more keywords