Use of liquid chromatography‐tandem mass spectrometry for determination of higenamine in urine following oral administration of traditional Chinese medicine
Sign Up to like & getrecommendations! Published in 2022 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3278
Abstract: Abstract Since higenamine (HG) was first included in the World Anti‐doping Agency (WADA) 2017 Prohibited List, an increasing number of plants have been found to contain this ingredient. As a result, doctors are hesitant to… read more here.
Keywords: administration; following oral; chinese medicine; oral administration ... See more keywords
Vaginal concentrations of SCY‐078, a novel glucan synthesis inhibitor, following oral administration in mice: 23
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Obstetrics and Gynecology"
DOI: 10.1016/j.ajog.2017.08.044
Abstract: Blood, vulvovaginal tissue and vaginal secretions were collected pre-dose, and at 1, 2, 4, 6, 8, 12, 18 and 24 hours post-dose, following the final dose administered per group. Samples were then processed, extracted via… read more here.
Keywords: scy 078; following oral; concentrations scy; vaginal concentrations ... See more keywords
Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0107-4
Abstract: Addiction has been proposed as a ‘reward deficient’ state, which is compensated for with substance use. There is growing evidence of dysregulation in the opioid system, which plays a key role in reward, underpinning addiction.… read more here.
Keywords: endogenous opioid; opioid release; mor availability; following oral ... See more keywords
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration
Sign Up to like & getrecommendations! Published in 2023 at "Xenobiotica"
DOI: 10.1080/00498254.2023.2179952
Abstract: Abstract The metabolism and pharmacokinetics of fasiglifam (TAK-875, 2-[(3S)-6-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid), a selective free fatty acid receptor 1 (FFAR1)/GPR40 agonist, were studied following intravenous (5 mg/kg) and oral administration (10 and 50 mg/kg) to male and female Sprague… read more here.
Keywords: female rats; rats following; following oral; tak 875 ... See more keywords
Current and emerging COX inhibitors for treating postoperative pain following oral surgery
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2161364
Abstract: ABSTRACT Introduction The numerous drugs in the NSAID class are often used to treat acute postoperative pain associated with oral surgery such as impacted third-molar extractions. These drugs are effective in this setting and dental… read more here.
Keywords: cox inhibitors; following oral; postoperative pain; pain ... See more keywords
SCY-078 Demonstrates Significant Tissue Penetration in Rats and Mice Following Oral or IV Administration
Sign Up to like & getrecommendations! Published in 2017 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofx163.1204
Abstract: Abstract Background The ability of a pharmacologic agent to reach target organ(s) in therapeutically-meaningful concentrations is one of the fundamental considerations when developing effective, anti-infective treatments. SCY-078 is a novel, oral and intravenous (IV), triterpenoid… read more here.
Keywords: administration; plasma; following oral; penetration ... See more keywords
Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans
Sign Up to like & getrecommendations! Published in 2023 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfad004
Abstract: Abstract HFPO-DA (ammonium, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate) is a short-chain polyfluorinated alkyl substance (PFAS) used in the manufacture of some types of fluorinated polymers. Like many PFAS, toxicity studies with HFPO-DA indicate the liver is the primary target… read more here.
Keywords: hfpo; mode action; following oral; oral exposure ... See more keywords
Pharmacokinetics of fluoxetine in horses following oral administration.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.13029
Abstract: This study aimed to investigate pharmacokinetics of fluoxetine in horses and validate a method for liquid chromatography mass spectrometry analysis of serum levels. Fluoxetine pharmacokinetics were determined using 10 healthy, adult horses. Fluoxetine pharmacokinetics following a… read more here.
Keywords: administration; following oral; serum; pharmacokinetics fluoxetine ... See more keywords
Concentrations, pharmacokinetics and selected pharmacodynamics of morphine and its active metabolites following oral administration to horses.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.13122
Abstract: The metabolism and pharmacokinetics of intravenous (i.v.) morphine in the horse have been described; however, administration of therapeutic doses has also been associated with neuroexcitation and adverse gastrointestinal effects. In this study, we hypothesized that… read more here.
Keywords: administration; concentrations pharmacokinetics; following oral; pharmacokinetics selected ... See more keywords
Pathogenicity of La Jolla Virus in Drosophila suzukii following Oral Administration
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14102158
Abstract: Drosophila suzukii (Ds) is an invasive pest insect that causes severe and widespread damage to soft fruit crops. Chemical control based on topical insecticides is inefficient and harmful to consumers and the environment, prompting interest… read more here.
Keywords: drosophila suzukii; ljv; following oral; jolla virus ... See more keywords