A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1208
Abstract: This open‐label, randomized, 3‐treatment, 3‐period, 6‐sequence, crossover study in healthy subjects compared the pharmacokinetic and pharmacodynamic properties of a lipid‐based (soft gelatin capsule) prototype final market image (pFMI) formulation of tropifexor (90‐µg) to its clinical… read more here.
Keywords: formulation; csf; food; concentration ... See more keywords
Predicting Food Effect On Oral Drug Absorption For Solubility-Epithelial Membrane Permeation-Limited Cases With Bile Micelle Solubilization
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DOI: 10.1007/s11095-025-03947-8
Abstract: The purpose of this study was to investigate the theoretical and in vitro experimental prediction of food effects on oral drug absorption, focusing on solubility-epithelial membrane permeation-limited cases (SL-E). Bosentan, fidaxomicin, pranlukast, and rifaximin were… read more here.
Keywords: limited cases; food; permeation limited; food effect ... See more keywords
Minimal food effect for eicosapentaenoic acid and docosahexaenoic acid bioavailability from omega-3-acid ethyl esters with an Advanced Lipid TechnologiesTM (ALT®)-based formulation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2017.01.017
Abstract: BACKGROUND The absorption of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) omega-3-acid ethyl esters (EEs) is influenced by food. There is a need for a formulation of EE that is less impacted by… read more here.
Keywords: low fat; food effect; dha; acid ... See more keywords
Enhanced oral bioavailability and diminished food effect of lurasidone hydrochloride nanosuspensions prepared by facile nanoprecipitation based on dilution
Sign Up to like & getrecommendations! Published in 2017 at "Powder Technology"
DOI: 10.1016/j.powtec.2017.02.038
Abstract: Abstract The aim of this study was to improve the oral bioavailability and diminish the food effect of a poorly soluble drug with pH-dependent solubility, lurasidone hydrochloride (LH), by fabricating its nanosuspensions using a facile… read more here.
Keywords: oral bioavailability; food effect; bioavailability; facile nanoprecipitation ... See more keywords
Biopharmaceutical Modeling of Food Effect─Exploring the Role of Dietary Fat.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00170
Abstract: In preclinical drug discovery, simple fraction absorbed calculators are exceptionally valuable tools to better understand the potential limitations to drug absorption and how different formulation approaches may address them. These tools often struggle to accurately… read more here.
Keywords: food; model; food effect; absorption ... See more keywords
Formulation optimization and pharmacokinetics evaluation of oral self-microemulsifying drug delivery system for poorly water soluble drug cinacalcet and no food effect
Sign Up to like & getrecommendations! Published in 2018 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2018.1425428
Abstract: Abstract The present research indicated that a new self-microemulsifying drug delivery systems (SMEDDS) were used to reduce the food effect of poorly water-soluble drug cinacalcet and enhance the bioavailability in beagle dogs by oral gavage.… read more here.
Keywords: methodology; food effect; drug; effect ... See more keywords
Consideration on Food Effect Studies for Anticancer Drugs Approved in Japan Between 2001 and 2022
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Translational Science"
DOI: 10.1111/cts.70304
Abstract: ABSTRACT In developing a new drug, studies to evaluate the food effect (FE) on the drug's pharmacokinetics (FE studies) are generally conducted in healthy subjects in the early stages of clinical development. Conversely, for anticancer… read more here.
Keywords: healthy subjects; drugs approved; food effect; approved japan ... See more keywords
Novel formulation of abiraterone acetate with significantly higher bioavailability and eliminated food effect might allow higher abiraterone exposure and better patient outcome.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e17036
Abstract: e17036Background: Zytiga (Abiraterone acetate, AA) is known to exhibit very low bioavailability and a significant positive food effect. This is attributed to the inadequate and variable dissolution... read more here.
Keywords: food effect; abiraterone; abiraterone acetate; bioavailability ... See more keywords
Investigating the Mechanisms behind the Positive Food Effect of Abiraterone Acetate: In Vitro and Rat In Situ Studies
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DOI: 10.3390/pharmaceutics14050952
Abstract: The anticancer agent abiraterone suffers from an extensive positive food effect after oral intake of the prodrug abiraterone acetate (Zytiga). The underlying processes determining postprandial abiraterone absorption were investigated in this study. The impact of… read more here.
Keywords: abiraterone; positive food; abiraterone acetate; food effect ... See more keywords