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Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1208
Abstract: This open‐label, randomized, 3‐treatment, 3‐period, 6‐sequence, crossover study in healthy subjects compared the pharmacokinetic and pharmacodynamic properties of a lipid‐based (soft gelatin capsule) prototype final market image (pFMI) formulation of tropifexor (90‐µg) to its clinical…
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Keywords:
formulation;
csf;
food;
concentration ... See more keywords
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Published in 2017 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2017.01.017
Abstract: BACKGROUND The absorption of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) omega-3-acid ethyl esters (EEs) is influenced by food. There is a need for a formulation of EE that is less impacted by…
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Keywords:
low fat;
food effect;
dha;
acid ... See more keywords
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Published in 2017 at "Powder Technology"
DOI: 10.1016/j.powtec.2017.02.038
Abstract: Abstract The aim of this study was to improve the oral bioavailability and diminish the food effect of a poorly soluble drug with pH-dependent solubility, lurasidone hydrochloride (LH), by fabricating its nanosuspensions using a facile…
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Keywords:
oral bioavailability;
food effect;
bioavailability;
facile nanoprecipitation ... See more keywords
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3
Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00170
Abstract: In preclinical drug discovery, simple fraction absorbed calculators are exceptionally valuable tools to better understand the potential limitations to drug absorption and how different formulation approaches may address them. These tools often struggle to accurately…
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Keywords:
food;
model;
food effect;
absorption ... See more keywords
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0
Published in 2018 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2018.1425428
Abstract: Abstract The present research indicated that a new self-microemulsifying drug delivery systems (SMEDDS) were used to reduce the food effect of poorly water-soluble drug cinacalcet and enhance the bioavailability in beagle dogs by oral gavage.…
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Keywords:
methodology;
food effect;
drug;
effect ... See more keywords
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Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e17036
Abstract: e17036Background: Zytiga (Abiraterone acetate, AA) is known to exhibit very low bioavailability and a significant positive food effect. This is attributed to the inadequate and variable dissolution...
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Keywords:
food effect;
abiraterone;
abiraterone acetate;
bioavailability ... See more keywords
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2
Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14050952
Abstract: The anticancer agent abiraterone suffers from an extensive positive food effect after oral intake of the prodrug abiraterone acetate (Zytiga). The underlying processes determining postprandial abiraterone absorption were investigated in this study. The impact of…
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Keywords:
abiraterone;
positive food;
abiraterone acetate;
food effect ... See more keywords