Ultra-stable biomembrane force probe for accurately determining slow dissociation kinetics of PD-1 blockade antibodies on single living cells.
Sign Up to like & getrecommendations! Published in 2020 at "Nano letters"
DOI: 10.1021/acs.nanolett.0c01360
Abstract: Immune checkpoint blockade with monoclonal antibodies (mAbs) that target programmed cell death protein-1 (PD-1) has remarkably revolutionized cancer therapy. Their binding kinetics measured by surface plasmon resonance do not always correlate well with their immunotherapeutic… read more here.
Keywords: force probe; ultra stable; dissociation kinetics; biomembrane force ... See more keywords
Ratiometric Flapping Force Probe That Works in Polymer Gels.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12955
Abstract: Polymer gels have recently attracted attention for their application in flexible devices, where mechanically robust gels are required. While there are many strategies to produce tough gels by suppressing nanoscale stress concentration on specific polymer… read more here.
Keywords: flap; force probe; polymer gels; force ... See more keywords