Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans
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DOI: 10.1038/s41467-021-25435-4
Abstract: TRP channel-associated factor 1/2 (TCAF1/TCAF2) proteins antagonistically regulate the cold-sensor protein TRPM8 in multiple human tissues. Understanding their significance has been complicated given the locus spans a gap-ridden region with complex segmental duplications in GRCh38.… read more here.
Keywords: selective forces; forces operating; opposing selective; evidence opposing ... See more keywords