Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22700
Abstract: Down syndrome (DS), trisomy 21, is marked by intellectual disability and a premature aging profile including degeneration of the basal forebrain cholinergic neuron (BFCN) projection system, similar to Alzheimer's disease (AD). Although data indicate that… read more here.
Keywords: cholinergic neuron; choline; choline supplementation; maternal choline ... See more keywords
Retrograde Axonal Transport of Neurotrophins in Basal Forebrain Cholinergic Neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1990-2_13
Abstract: Axonal transport is key for the survival and function of all neurons. This process is especially important in basal forebrain cholinergic neurons due to their extremely long and diffuse axonal projections. These neurons are critical… read more here.
Keywords: transport; axonal transport; biology; cholinergic neurons ... See more keywords
Increase in cortical endocannabinoid signaling in a rat model of basal forebrain cholinergic dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.08.008
Abstract: The basal forebrain cholinergic pathways progressively degenerate during the progression of Alzheimer's disease, leading to an irreversible impairment of memory and thinking skills. The stereotaxic lesion with 192IgG-saporin in the rat brain has been used… read more here.
Keywords: basal; ecb; basal forebrain; forebrain cholinergic ... See more keywords
Adolescent binge ethanol exposure alters specific forebrain cholinergic cell populations and leads to selective functional deficits in the prefrontal cortex
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.08.013
Abstract: Adolescence has been identified as a vulnerable developmental time period during which exposure to drugs can have long-lasting, detrimental effects. Although adolescent binge-like ethanol (EtOH) exposure leads to a significant reduction in forebrain cholinergic neurons,… read more here.
Keywords: ethanol exposure; exposure; forebrain cholinergic; adolescent binge ... See more keywords
Parallel Atrophy of Cortex and Basal Forebrain Cholinergic System in Mild Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2017 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhw019
Abstract: Abstract The basal forebrain cholinergic system (BFCS) is the major source of acetylcholine for the cerebral cortex in humans. The aim was to analyze the pattern of BFCS and cortical atrophy in MCI patients to… read more here.
Keywords: cortex; parallel atrophy; basal forebrain; forebrain cholinergic ... See more keywords
Acetylcholine modulates K+ and Na+ currents in human basal forebrain cholinergic neuroblasts through an autocrine/paracrine mechanism
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15209
Abstract: The Nucleus Basalis of Meynert (NBM) is the main source of cholinergic neurons in the basal forebrain to be crucially involved in cognitive functions and whose degeneration correlates with cognitive decline in major degenerative pathologies… read more here.
Keywords: human basal; acetylcholine modulates; basal forebrain; currents human ... See more keywords
Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-020-00411-6
Abstract: Background Alzheimer’s disease (AD) is an adult-onset mental disorder with aging as a major risk factor. Early and progressive degeneration of basal forebrain cholinergic neurons (BFCNs) contributes substantially to cognitive impairments of AD. An aging-relevant… read more here.
Keywords: alzheimer disease; cholinergic neurons; cell model; aging relevant ... See more keywords
Adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons and neuroimmune activation are prevented by exercise and indomethacin
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0204500
Abstract: Basal forebrain cholinergic neurons mature in adolescence coinciding with development of adult cognitive function. Preclinical studies using the rodent model of adolescent intermittent ethanol (AIE; 5.0 g/kg, i.g., 2-days on/2-days off from postnatal day [P]25… read more here.
Keywords: cholinergic neurons; basal; basal forebrain; ethanol ... See more keywords
Developmental regulation of GABAergic gene expression in forebrain cholinergic neurons
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2023.1125071
Abstract: Acetylcholine and GABA are often co-released, including from VIP-expressing neurons of the cortex, cortically-projecting neurons of the globus pallidus externus and basal forebrain, and hippocampal-projecting neurons of the medial septum. The co-release of the functionally… read more here.
Keywords: cholinergic neurons; expression; regulation gabaergic; gaba ... See more keywords
The Basal Forebrain Cholinergic Nuclei and Their Relevance to Schizophrenia and Other Psychotic Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.909961
Abstract: The basal forebrain cholinergic nuclei (BFCN) provide the main cholinergic input to prefrontal cortices, the hippocampi, and amygdala. These structures are highly relevant for the regulation and maintenance of many cognitive functions, such as attention… read more here.
Keywords: nuclei relevance; psychotic disorders; cholinergic nuclei; schizophrenia ... See more keywords
Tumor Necrosis Factor α Influences Phenotypic Plasticity and Promotes Epigenetic Changes in Human Basal Forebrain Cholinergic Neuroblasts
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21176128
Abstract: TNFα is the main proinflammatory cytokine implicated in the pathogenesis of neurodegenerative disorders, but it also modulates physiological functions in both the developing and adult brain. In this study, we investigated a potential direct role… read more here.
Keywords: cholinergic neuroblasts; human basal; tnf; phenotypic plasticity ... See more keywords