Keeping the strands together: Rad53 regulation of fork symmetry promotes replication stability
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200141
Abstract: DNAreplicationduringthesynthesis(S-)phaseofthecellcycleisakey step in cell proliferation. DNA replication fidelity and cell cycle checkpoints ensure that transient DNA damage is not converted into stable mutations.Thesedirectlinkstocellproliferationandmutationalavoid-ancemakeDNAreplicationcheckpointsimportanttogenomestability. He and Zhang’s Hypothesis explores how DNA replication complexes are maintained during… read more here.
Keywords: strands together; dna; replication; fork ... See more keywords
Influence of $$^4$$4He Coverage on Resonance Properties of a Quartz Tuning Fork Immersed in Liquid $$^3$$3He
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Low Temperature Physics"
DOI: 10.1007/s10909-016-1673-y
Abstract: Nowadays quartz tuning forks are commonly used for temperature measurements in experiments with liquid (both normal and superfluid) $$^3$$3He. In most of the experiments pure $$^3$$3He is used, but in some cases $$^4$$4He is added… read more here.
Keywords: 4he coverage; quartz tuning; fork; influence 4he ... See more keywords
Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107635
Abstract: Expanded CAG repeats form stem-loop secondary structures that lead to fork stalling and collapse. Previous work has shown that these collapsed forks relocalize to nuclear pore complexes (NPCs) in late S phase in a manner… read more here.
Keywords: sumoylation; dna repair; fork; repair proteins ... See more keywords
DCAF14 promotes stalled fork stability to maintain genome integrity
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DOI: 10.1016/j.celrep.2020.108669
Abstract: SUMMARY Replication stress response ensures impediments to DNA replication do not compromise replication fork stability and genome integrity. In a process termed replication fork protection, newly synthesized DNA at stalled replication forks is stabilized and… read more here.
Keywords: stalled fork; fork stability; fork; genome integrity ... See more keywords
Unhooking of an interstrand cross-link at DNA fork structures by the DNA glycosylase NEIL3.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.102752
Abstract: Interstrand DNA-DNA cross-links (ICLs) are generated by endogenous processes, drugs, and environmental toxins. Understanding the cellular pathways by which various ICLs are repaired is critical to understanding their biological effects. Recent studies showed that replication-dependent… read more here.
Keywords: dna; icl; dna glycosylase; fork ... See more keywords
PARP activity fine-tunes the DNA replication choreography of Chk1-depleted cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.166949
Abstract: Checkpoint Kinase 1 (Chk1) prevents DNA damage by adjusting the replication choreography in the face of replication stress. Chk1 depletion provokes slow and asymmetrical fork movement, yet the signals governing such changes remain unclear. We… read more here.
Keywords: chk1; replication choreography; fork; chk1 depleted ... See more keywords
O10 From Idea to Reality: Addressing College Food Insecurity with a Farm-to-Fork Initiative
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Nutrition Education and Behavior"
DOI: 10.1016/j.jneb.2019.05.316
Abstract: Objective To develop, implement, and evaluate Farm-to-Fork, a free weekly meal program for college students that integrates social, sustainable, local, and educational elements at the University of Kentucky (UK). Use of Theory or Research Of… read more here.
Keywords: farm fork; food insecurity; college; fork ... See more keywords
PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.08.018
Abstract: Stabilization of stalled replication forks is a prominent mechanism of PARP (Poly(ADP-ribose) Polymerase) inhibitor (PARPi) resistance in BRCA-deficient tumors. Epigenetic mechanisms of replication fork stability are emerging but remain poorly understood. Here, we report the… read more here.
Keywords: mre11 exo1; deficient cells; deficient; fork ... See more keywords
Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation
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DOI: 10.1038/s41467-019-09196-9
Abstract: Stabilisation of stalled replication forks prevents excessive fork reversal and their pathological degradation, which can undermine genome integrity. Here we investigate a physiological role of RAD52 at stalled replication forks by using human cell models… read more here.
Keywords: degradation; fork; prevents excessive; stalled replication ... See more keywords
SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19162-5
Abstract: Protecting replication fork integrity during DNA replication is essential for maintaining genome stability. Here, we report that SDE2, a PCNA-associated protein, plays a key role in maintaining active replication and counteracting replication stress by regulating… read more here.
Keywords: sde2 integrates; fork; replication forks; tim ... See more keywords
Fork-tip needle biopsy versus fine-needle aspiration in endoscopic ultrasound-guided sampling of solid pancreatic masses: a randomized crossover study.
Sign Up to like & getrecommendations! Published in 2020 at "Endoscopy"
DOI: 10.1055/a-1114-5903
Abstract: BACKGROUND A novel fork-tip fine-needle biopsy (FNB) needle has recently been introduced for endoscopic ultrasound (EUS)-guided sampling. The aim of this study was to compare the performance of fork-tip FNB histology and standard fine-needle aspiration… read more here.
Keywords: guided sampling; fork tip; diagnosis; fork ... See more keywords