RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress
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DOI: 10.1101/2022.03.25.485778
Abstract: Solving the problems that replication forks encounter when synthesizing DNA is essential to prevent genomic instability. Besides their role in DNA repair in the G2 phase, several homologous recombination proteins, specifically Rad51, have prominent roles… read more here.
Keywords: dna; replication fork; replication; fork progression ... See more keywords
Dynamic changes in ORC localization and replication fork progression during tissue differentiation
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DOI: 10.1186/s12864-018-4992-3
Abstract: BackgroundGenomic regions repressed for DNA replication, resulting in either delayed replication in S phase or underreplication in polyploid cells, are thought to be controlled by inhibition of replication origin activation. Studies in Drosophila polytene cells,… read more here.
Keywords: replication fork; fork progression; replication; tissue ... See more keywords
Chl1 helicase controls replication fork progression by regulating dNTP pools
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DOI: 10.26508/lsa.202101153
Abstract: Chl1 helicase affects RPA-dependent checkpoint activation after replication fork arrest by ensuring proper dNTP levels, thereby controlling replication fork progression under stress conditions. Eukaryotic cells have evolved a replication stress response that helps to overcome… read more here.
Keywords: replication fork; dntp; replication; fork progression ... See more keywords