Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1819107116
Abstract: Significance Fork regression is a way of circumventing or dealing with DNA lesions and is important to genome integrity. Fork regression is performed by double-strand DNA ATPases that initially cause newly synthesized strands to unpair… read more here.
Keywords: cmg; regression; dna; fork regression ... See more keywords
Replication fork regression and its regulation.
Sign Up to like & getrecommendations! Published in 2017 at "FEMS yeast research"
DOI: 10.1093/femsyr/fow110
Abstract: One major challenge during genome duplication is the stalling of DNA replication forks by various forms of template blockages. As these barriers can lead to incomplete replication, multiple mechanisms have to act concertedly to correct… read more here.
Keywords: replication fork; regression; fork regression; replication forks ... See more keywords
Werner syndrome protein works as a dimer for unwinding and replication fork regression
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1200
Abstract: Abstract The determination of the oligomeric state of functional enzymes is essential for the mechanistic understanding of their catalytic activities. RecQ helicases have diverse biochemical activities, but it is still unclear how their activities are… read more here.
Keywords: replication; replication fork; fork regression; unwinding replication ... See more keywords
The Biochemical Mechanism of Fork Regression in Prokaryotes and Eukaryotes—A Single Molecule Comparison
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DOI: 10.3390/ijms23158613
Abstract: The rescue of stalled DNA replication forks is essential for cell viability. Impeded but still intact forks can be rescued by atypical DNA helicases in a reaction known as fork regression. This reaction has been… read more here.
Keywords: single molecule; fork regression; fork; biochemical mechanism ... See more keywords