Regulation of replication fork speed: Mechanisms and impact on genomic stability.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.102654
Abstract: Replication of DNA is a fundamental biological process that ensures precise duplication of the genome and thus safeguards inheritance. Any errors occurring during this process must be repaired before the cell divides, by activating the… read more here.
Keywords: replication fork; dna; fork speed; speed ... See more keywords
The need to regulate replication fork speed
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aaq0678
Abstract: Fork speed modulation counteracts redox imbalance to safeguard genome integrity The integrity of DNA is constantly threatened by the molecules that are endogenously generated by cell metabolism, the most common by-product being reactive oxygen species… read more here.
Keywords: replication fork; replication; fork speed; dna ... See more keywords