The regulatory domains of the lipid exporter ABCA1 form domain swapped latches
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DOI: 10.1371/journal.pone.0262746
Abstract: ABCA1 and ABCA4 are enigmatic because they transport substrates in opposite directions yet share >50% amino acid identity. ABCA4 imports lipid conjugates but ABCA1 exports lipids. Both hydrolyze ATP to drive transport, and both contain… read more here.
Keywords: domain swapped; exporter; domain; regulatory domains ... See more keywords