Copper2+ Binding to α-Synuclein. Histidine50 Can Form a Ternary Complex with Cu2+ at the N-Terminus but Not a Macrochelate.
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DOI: 10.1021/acs.inorgchem.9b02644
Abstract: α-Synuclein (αSyn) forms amyloid fibrils in the neurons of Parkinson's disease (PD) patients'. Despite a role for Cu2+ in accelerating αSyn fibril formation, coupled with reports of copper dis-homeostasis in PD, there remain controversies surrounding… read more here.
Keywords: ternary complex; macrochelate; form ternary; cu2 ... See more keywords