Formal [3+3] Cyclization Between 3‐Alkynyl‐3‐hydroxyisoindolinones and Substituted Phenols to 2 H ‐Chromene Based Spiro ‐isoindolinones
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DOI: 10.1002/ajoc.70260
Abstract: We herein reported a formal [3+3] cyclization reaction between 3‐alkynyl‐3‐hydroxyisoindolinones and substituted phenols, which offered an efficient procedure for the preparation of 2 H ‐chromene‐based spiro ‐isoindolinones. 10 mol% of inexpensive catalyst (Cu(ClO 4 )… read more here.
Keywords: substituted phenols; formal cyclization; hydroxyisoindolinones substituted; chromene based ... See more keywords
Construction of Novel Tetrahydro‐β‐carboline‐1‐thione Spirooxindoles by Brønsted Acid Mediated Formal [3+3] Cyclization of 3‐Indolylmethanols with 3‐Isothiocyanato Oxindoles
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DOI: 10.1002/jhet.2708
Abstract: p-Toluenesulfonic acid mediated formal [3+3] cyclization of 3-indolylmethanols with 3-isothiocyanato oxindoles was realized. This transformation allowed for the synthesis of a series of novel tetrahydro-β-carboline-1-thione spirooxindoles in moderate to excellent yields (up to 99%) with… read more here.
Keywords: acid mediated; mediated formal; indolylmethanols isothiocyanato; cyclization indolylmethanols ... See more keywords
Benzenediazonium Tetrafluoroborate‐Catalyzed Formal [3 + 3] Cyclization of 4‐Hydroxycoumarins With Propargylicalcohols
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DOI: 10.1002/jhet.4912
Abstract: A formal [3 + 3] cycloaddition of 4‐hydroxycoumarins with propargylicalcohols was established under mild conditions. This strategy utilizes diazonium tetrafluoroborate as the Lewis acid catalyst and provides a practical approach for delivering pyranocoumarin derivatives in moderate to… read more here.
Keywords: hydroxycoumarins propargylicalcohols; catalyzed formal; formal cyclization; benzenediazonium tetrafluoroborate ... See more keywords
Regioselective Formal (3+2) Cyclization of Propargylic para -Quinone Methides ( p -QMs) with β-Keto Carbonyls: Direct Access to (Fused)-Furans
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DOI: 10.1055/s-0043-1773538
Abstract: We report a calcium(II)-catalyzed, base-promoted, formal (3+2) cyclization of para -quinone methides with 1,3-dicarbonyl derivatives to access furans, dihydrofurans, dihydrobenzofurans, and naphthofurans under solvent-free conditions. The reaction shows good substrate generality and excellent regioselectivity. read more here.
Keywords: access; formal cyclization; quinone methides; para quinone ... See more keywords