Catalytic Asymmetric Addition Reactions of Formaldehyde N,N-Dialkylhydrazone to Synthesize Chiral Nitrile Derivatives.
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DOI: 10.1021/acs.orglett.0c01857
Abstract: A number of nitrile-containing chiral molecules were synthesized via asymmetric nucleophilic addition of formaldehyde N,N-dialkylhydrazone as the nitrile equivalent. Chiral N,N'-dioxide/metal salt complexes enabled the asymmetric addition reactions to both isatin-derived imines and α,β-unsaturated ketones,… read more here.
Keywords: formaldehyde dialkylhydrazone; addition; asymmetric addition; addition reactions ... See more keywords